National Technical Reports Library

The National Technical Information Service acquires, indexes, abstracts, and archives the largest collection of U.S. government-sponsored technical reports in existence. The NTRL offers online, free and open access to these authenticated government technical reports. Technical reports and documents in its repository may be available online for free either from the issuing federal agency, the U.S. Government Publishing Office’s Federal Digital System website, or through search engines.

Details

New Method for Occupational Cancer Surveillance.

PB99167025

Publication Date	1999
Personal Author	Brandt-Rauf, P. W.
Page Count	10
Abstract	Biomarkers of response to exposure to occupational carcinogens may allow early detection of those individuals at risk for the development of occupational cancer. Since many occupation carcinogens appear to have an affect on oncogene activation in vitro, the detection of ocogene activation by assaying for the expression of oncogene encoded proteins in vivo via the detection of these proteins in serum may be a useful biomarker of response to exposure to occupational carcinogens. A serum immunoblotting assay based on monoclonal antibodies to oncogene protein sequences was used to investigate serum oncogene protein expression in cancer patients versus normal controls and in cohorts exposed to occupational carcinogens.
Keywords	Occupational diseases Cancers Carcinogens Exposure Surveillance Occupational safety and health Objectives Methodology Literature review
Source Agency	National Institute for Occupational Safety and Health
Corporate Authors	Columbia Univ., New York. School of Public Health.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Supplemental Notes	See also PB95-269890. Sponsored by National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
Title Note	Final rept. 15 Jul89-14 Jan 93.
NTIS Issue Number	199923

New Method for Occupational Cancer Surveillance.

New Method for Occupational Cancer Surveillance.
PB99167025

Publication Date	1999
Personal Author	Brandt-Rauf, P. W.
Page Count	10
Abstract	Biomarkers of response to exposure to occupational carcinogens may allow early detection of those individuals at risk for the development of occupational cancer. Since many occupation carcinogens appear to have an affect on oncogene activation in vitro, the detection of ocogene activation by assaying for the expression of oncogene encoded proteins in vivo via the detection of these proteins in serum may be a useful biomarker of response to exposure to occupational carcinogens. A serum immunoblotting assay based on monoclonal antibodies to oncogene protein sequences was used to investigate serum oncogene protein expression in cancer patients versus normal controls and in cohorts exposed to occupational carcinogens.
Keywords	Occupational diseases Cancers Carcinogens Exposure Surveillance Occupational safety and health Objectives Methodology Literature review
Source Agency	National Institute for Occupational Safety and Health
Corporate Authors	Columbia Univ., New York. School of Public Health.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Supplemental Notes	See also PB95-269890. Sponsored by National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
Title Note	Final rept. 15 Jul89-14 Jan 93.
NTIS Issue Number	199923