National Technical Reports Library

The National Technical Information Service acquires, indexes, abstracts, and archives the largest collection of U.S. government-sponsored technical reports in existence. The NTRL offers online, free and open access to these authenticated government technical reports. Technical reports and documents in its repository may be available online for free either from the issuing federal agency, the U.S. Government Publishing Office’s Federal Digital System website, or through search engines.

Details

Final Report on the Developmental Toxicity of Formamide (CAS No. 75-12-7) Administered by Gavage to Sprague-Dawley CD (Trade Name) Rats on Gestational Days 6-19.

PB99139701

Publication Date	1998
Page Count	106
Abstract	Formamide (FORM) is a widely used industrial solvent, and its developmental toxicity in laboratory species has been reported previously. This study was performed due to the lack of data from pregnant rats exposed during the entire embryo/fetal period. Dose selection was based on a screening study in which CD rats were treated by gavage with 0, 62, 125, 250, 500, or 1000 mg FORM/kg body weight/day on gestational days (gd) 6-19 (NTP, 1998). Maternal toxicity was noted at = or > 250 mg/kg/day, including morbidity, and reductions in water/food intake, body weight, and weight gain. Fetal body weight was reduced at = or > 125 mg/kg/day (NTP, 1998).
Keywords	Toxicity Formamide Pregnancy Rats Laboratory animals Gavage Ingestion Solvents Dosage CAS No. 75-12-7
Source Agency	National Institute of Environmental Health Sciences
Corporate Authors	Research Triangle Inst., Research Triangle Park, NC.; National Toxicology Program, Research Triangle Park, NC.
Supplemental Notes	Sponsored by National Toxicology Program, Research Triangle Park, NC.
Document Type	Technical Report
NTIS Issue Number	199914

Final Report on the Developmental Toxicity of Formamide (CAS No. 75-12-7) Administered by Gavage to Sprague-Dawley CD (Trade Name) Rats on Gestational Days 6-19.

Final Report on the Developmental Toxicity of Formamide (CAS No. 75-12-7) Administered by Gavage to Sprague-Dawley CD (Trade Name) Rats on Gestational Days 6-19.
PB99139701

Publication Date	1998
Page Count	106
Abstract	Formamide (FORM) is a widely used industrial solvent, and its developmental toxicity in laboratory species has been reported previously. This study was performed due to the lack of data from pregnant rats exposed during the entire embryo/fetal period. Dose selection was based on a screening study in which CD rats were treated by gavage with 0, 62, 125, 250, 500, or 1000 mg FORM/kg body weight/day on gestational days (gd) 6-19 (NTP, 1998). Maternal toxicity was noted at = or > 250 mg/kg/day, including morbidity, and reductions in water/food intake, body weight, and weight gain. Fetal body weight was reduced at = or > 125 mg/kg/day (NTP, 1998).
Keywords	Toxicity Formamide Pregnancy Rats Laboratory animals Gavage Ingestion Solvents Dosage CAS No. 75-12-7
Source Agency	National Institute of Environmental Health Sciences
Corporate Authors	Research Triangle Inst., Research Triangle Park, NC.; National Toxicology Program, Research Triangle Park, NC.
Supplemental Notes	Sponsored by National Toxicology Program, Research Triangle Park, NC.
Document Type	Technical Report
NTIS Issue Number	199914