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Final Report on the Developmental Toxicity of Formamide (CAS No. 75-12-7) Administered by Gavage to Sprague-Dawley CD (Trade Name) Rats on Gestational Days 6-19.


PB99139701

Publication Date 1998
Page Count 106
Abstract Formamide (FORM) is a widely used industrial solvent, and its developmental toxicity in laboratory species has been reported previously. This study was performed due to the lack of data from pregnant rats exposed during the entire embryo/fetal period. Dose selection was based on a screening study in which CD rats were treated by gavage with 0, 62, 125, 250, 500, or 1000 mg FORM/kg body weight/day on gestational days (gd) 6-19 (NTP, 1998). Maternal toxicity was noted at = or > 250 mg/kg/day, including morbidity, and reductions in water/food intake, body weight, and weight gain. Fetal body weight was reduced at = or > 125 mg/kg/day (NTP, 1998).
Keywords
  • Toxicity
  • Formamide
  • Pregnancy
  • Rats
  • Laboratory animals
  • Gavage
  • Ingestion
  • Solvents
  • Dosage
  • CAS No. 75-12-7
Source Agency
  • National Institute of Environmental Health Sciences
Corporate Authors Research Triangle Inst., Research Triangle Park, NC.; National Toxicology Program, Research Triangle Park, NC.
Supplemental Notes Sponsored by National Toxicology Program, Research Triangle Park, NC.
Document Type Technical Report
NTIS Issue Number 199914
Final Report on the Developmental Toxicity of Formamide (CAS No. 75-12-7) Administered by Gavage to Sprague-Dawley CD (Trade Name) Rats on Gestational Days 6-19.
Final Report on the Developmental Toxicity of Formamide (CAS No. 75-12-7) Administered by Gavage to Sprague-Dawley CD (Trade Name) Rats on Gestational Days 6-19.
PB99139701

  • Toxicity
  • Formamide
  • Pregnancy
  • Rats
  • Laboratory animals
  • Gavage
  • Ingestion
  • Solvents
  • Dosage
  • CAS No. 75-12-7
  • National Institute of Environmental Health Sciences
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