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Risk of Chronic Toxicity Associated with Exposure to Diisononyl Phthalate (DINP) in Children's Products.

PB99115867

Publication Date	1998
Personal Author	Babich, M. A.
Page Count	80
Abstract	Dialkyl phthalates are plasticizers that are used in products made from polyvinyl chloride (PVC), including teethers, rattles, and squeeze toys. Because plasticizers are not covalently bound to the PVC polymer, oral exposure can occur when children place PVC products into their mouths. In lifetime feeding studies in the rat and mouse, DINP exposure was toxic to the liver and other organs and increased the incidence of hepatocellular adenoma and carcinoma. In contrast to certain other phthalates such as di-(2-ethylhexyl) phthalate (DEHP), DINP had little or no effect on reproduction or development. The staff measured the migration of DINP from children's products using a laboratory method (impaction) previously used for DEHP. Migration rates did not correlate with the DINP content, manufacturing process, or wall thickness.
Keywords	Children Chronic exposure Toxicity Risk assessment Plasticizers Phthalates Polyvinyl chloride Consumer products Ingestion(Physiology) Histopathology Liver diseases Hepatocellular carcinoma Liver cell adenoma Diisononyl phthalate DINP(Diisononyl phthalate) Dialkyl phthalates
Source Agency	Consumer Product Safety Commission
Corporate Authors	Consumer Product Safety Commission, Bethesda, MD. Directorate for Epidemiology and Health Sciences.
Supplemental Notes	See also Executive Summary, PB99-115859.
Document Type	Technical Report
NTIS Issue Number	199906

Risk of Chronic Toxicity Associated with Exposure to Diisononyl Phthalate (DINP) in Children's Products.

Risk of Chronic Toxicity Associated with Exposure to Diisononyl Phthalate (DINP) in Children's Products.
PB99115867

Publication Date	1998
Personal Author	Babich, M. A.
Page Count	80
Abstract	Dialkyl phthalates are plasticizers that are used in products made from polyvinyl chloride (PVC), including teethers, rattles, and squeeze toys. Because plasticizers are not covalently bound to the PVC polymer, oral exposure can occur when children place PVC products into their mouths. In lifetime feeding studies in the rat and mouse, DINP exposure was toxic to the liver and other organs and increased the incidence of hepatocellular adenoma and carcinoma. In contrast to certain other phthalates such as di-(2-ethylhexyl) phthalate (DEHP), DINP had little or no effect on reproduction or development. The staff measured the migration of DINP from children's products using a laboratory method (impaction) previously used for DEHP. Migration rates did not correlate with the DINP content, manufacturing process, or wall thickness.
Keywords	Children Chronic exposure Toxicity Risk assessment Plasticizers Phthalates Polyvinyl chloride Consumer products Ingestion(Physiology) Histopathology Liver diseases Hepatocellular carcinoma Liver cell adenoma Diisononyl phthalate DINP(Diisononyl phthalate) Dialkyl phthalates
Source Agency	Consumer Product Safety Commission
Corporate Authors	Consumer Product Safety Commission, Bethesda, MD. Directorate for Epidemiology and Health Sciences.
Supplemental Notes	See also Executive Summary, PB99-115859.
Document Type	Technical Report
NTIS Issue Number	199906