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Stress Genes as Biomarkers of Mineral Dust Exposure.

PB98137763

Publication Date	1997
Personal Author	Timblin, C. R.
Page Count	12
Abstract	Occupational exposures to asbestos or silica is associated with the development of both nonmalignant and malignant pulmonary disease. Considerable evidence indicates that the mechanism of mineral dust toxicity involves the production of active oxygen species (AOS) catalyzed directly on the mineral surface or by phagocytic cells within the lung. Production of AOA in excess of cellular defenses creates an environment of oxidative stress for the cell. The molecular response of cells to stress is a reprogramming of gene expression to meet the new challenges of its environment. Oxidant-induced genes include: genes encoding antioxidant enzymes, proto-oncogenes.
Keywords	Mineral dust Genes Occupational safety and health Occupational exposure Stress genes Boimarkers Air pollution Asbestos Silica
Source Agency	National Institute for Occupational Safety and Health
Corporate Authors	Vermont Univ., Burlington. Dept. of Pathology.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Supplemental Notes	Sponsored by National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
NTIS Issue Number	199813

Stress Genes as Biomarkers of Mineral Dust Exposure.

Stress Genes as Biomarkers of Mineral Dust Exposure.
PB98137763

Publication Date	1997
Personal Author	Timblin, C. R.
Page Count	12
Abstract	Occupational exposures to asbestos or silica is associated with the development of both nonmalignant and malignant pulmonary disease. Considerable evidence indicates that the mechanism of mineral dust toxicity involves the production of active oxygen species (AOS) catalyzed directly on the mineral surface or by phagocytic cells within the lung. Production of AOA in excess of cellular defenses creates an environment of oxidative stress for the cell. The molecular response of cells to stress is a reprogramming of gene expression to meet the new challenges of its environment. Oxidant-induced genes include: genes encoding antioxidant enzymes, proto-oncogenes.
Keywords	Mineral dust Genes Occupational safety and health Occupational exposure Stress genes Boimarkers Air pollution Asbestos Silica
Source Agency	National Institute for Occupational Safety and Health
Corporate Authors	Vermont Univ., Burlington. Dept. of Pathology.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Supplemental Notes	Sponsored by National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
NTIS Issue Number	199813