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Role of Fe(II) in Dust Induced Carcinogenesis.


PB98130842

Publication Date 1998
Personal Author Huang, X.
Page Count 18
Abstract Increasing evidence demonstrates that an excess of lung cancer and stomach cancer has been observed in iron ore and steel factories workers. It has been shown that the incidence of cancer is related to exposure to mineal dusts. Ferrous iron (Fe2+) is capable of producing reactive oxygen species (ROS) such as OH(sup dot) and ferryl species (Fe4+=0) and may play an important role in dust-induced carcinogenesis and lung injury. The original specific aims of this project were: (1) To compare the carcinogenicity of Fe2+ ion in solution and Fe2+-containing dusts; (2) To determine the mechanism of Fe2+-containing dust-induced carcinogenesis; (3) To compare the responsiveness of oxidative stress-responsive transcription factors such as nuclear factor KB(NF-KB) and AP-1 to Fe2+ treatments.
Keywords
  • Environmental health
  • Ferrous iron
  • Carcinogenesis
  • Lung cancer
  • Stomach cancer
  • Dusts
  • Tables(Data)
  • Solutions
Source Agency
  • National Institute for Occupational Safety and Health
Corporate Authors New York Univ. Medical Center, Tuxedo Park. Dept. of Environmental Medicine.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Supplemental Notes Sponsored by National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type Technical Report
Title Note Rept. for 30 Sep 94-29 Sep 96.
NTIS Issue Number 199811
Role of Fe(II) in Dust Induced Carcinogenesis.
Role of Fe(II) in Dust Induced Carcinogenesis.
PB98130842

  • Environmental health
  • Ferrous iron
  • Carcinogenesis
  • Lung cancer
  • Stomach cancer
  • Dusts
  • Tables(Data)
  • Solutions
  • National Institute for Occupational Safety and Health
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