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Role of Fe(II) in Dust Induced Carcinogenesis.

PB98130842

Publication Date	1998
Personal Author	Huang, X.
Page Count	18
Abstract	Increasing evidence demonstrates that an excess of lung cancer and stomach cancer has been observed in iron ore and steel factories workers. It has been shown that the incidence of cancer is related to exposure to mineal dusts. Ferrous iron (Fe2+) is capable of producing reactive oxygen species (ROS) such as OH(sup dot) and ferryl species (Fe4+=0) and may play an important role in dust-induced carcinogenesis and lung injury. The original specific aims of this project were: (1) To compare the carcinogenicity of Fe2+ ion in solution and Fe2+-containing dusts; (2) To determine the mechanism of Fe2+-containing dust-induced carcinogenesis; (3) To compare the responsiveness of oxidative stress-responsive transcription factors such as nuclear factor KB(NF-KB) and AP-1 to Fe2+ treatments.
Keywords	Environmental health Ferrous iron Carcinogenesis Lung cancer Stomach cancer Dusts Tables(Data) Solutions
Source Agency	National Institute for Occupational Safety and Health
Corporate Authors	New York Univ. Medical Center, Tuxedo Park. Dept. of Environmental Medicine.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Supplemental Notes	Sponsored by National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
Title Note	Rept. for 30 Sep 94-29 Sep 96.
NTIS Issue Number	199811

Role of Fe(II) in Dust Induced Carcinogenesis.

Role of Fe(II) in Dust Induced Carcinogenesis.
PB98130842

Publication Date	1998
Personal Author	Huang, X.
Page Count	18
Abstract	Increasing evidence demonstrates that an excess of lung cancer and stomach cancer has been observed in iron ore and steel factories workers. It has been shown that the incidence of cancer is related to exposure to mineal dusts. Ferrous iron (Fe2+) is capable of producing reactive oxygen species (ROS) such as OH(sup dot) and ferryl species (Fe4+=0) and may play an important role in dust-induced carcinogenesis and lung injury. The original specific aims of this project were: (1) To compare the carcinogenicity of Fe2+ ion in solution and Fe2+-containing dusts; (2) To determine the mechanism of Fe2+-containing dust-induced carcinogenesis; (3) To compare the responsiveness of oxidative stress-responsive transcription factors such as nuclear factor KB(NF-KB) and AP-1 to Fe2+ treatments.
Keywords	Environmental health Ferrous iron Carcinogenesis Lung cancer Stomach cancer Dusts Tables(Data) Solutions
Source Agency	National Institute for Occupational Safety and Health
Corporate Authors	New York Univ. Medical Center, Tuxedo Park. Dept. of Environmental Medicine.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Supplemental Notes	Sponsored by National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
Title Note	Rept. for 30 Sep 94-29 Sep 96.
NTIS Issue Number	199811