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Slilica, Silicosis, and Lung Cancer in Diatomite Workers.

PB97207120

Publication Date	1996
Personal Author	Checkoway, H.; Heyer, N. J.; Seixas, N. S.; Welp, E. A. E.; Demers, P. A.; Hughes, J. M.; Weill, H.
Page Count	56
Abstract	The project served to update a cohort mortality study of workers exposed to crystalline silica (14808607), primarily as cristobalite (14464461). Exposure occurred during the mining and processing of diatomaceous-earth in two facilities located in California. There were 2,961 workers in the cohort who had at least 12 months of cumulative service at either facility. This update extended an earlier study by 7 years. Mortality was followed up for 1942 through 1994. Chest radiographs were obtained for 2,520 workers. As expected, radiographcally determined silicosis was strongly related to cumulative exposure to crystalline silica. Compared to national rates, mortality rates from both nonmalignant respiratory disease and lung cancer were elevated among these workers. A strong dose response association was noted for cumulative exposure to crystalline silica and mortality from nonmalignant respiratory diseases. Lung cancer mortality was also associated with cumulative exposure to crystalline silica, but the association was not as strong as that from nonmalignant respiratory disease. Confounding by either smoking or by occupational asbestos (1332214) exposure was not likely to account for the observed exposure/response relations with nonmalignant respiratory disease and lung cancer mortality.
Keywords	Occupational safety and health Silica dusts Lung cancer Pulmonary system disorders Morality Risk factors Epidemiology Respiratory system disorders Mining industry
Source Agency	National Institute for Occupational Safety and Health
Corporate Authors	Washington Univ., Seattle. Dept. of Environmental Health.; British Columbia Univ., Vancouver. Occupational Hygiene Programme.; National Inst. for Occupational Safety and Health, Cincinnati, OH.; Tulane Univ. Medical Center, New Orleans, LA. Section of Environmental
Supplemental Notes	Prepared in cooperation with British Columbia Univ., Vancouver. Occupational Hygiene Programme. and Tulane Univ. Medical Center, New Orleans, LA. Section of Environmental Medicine. Sponsored by National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
Title Note	Final rept.
NTIS Issue Number	199724

Slilica, Silicosis, and Lung Cancer in Diatomite Workers.

Slilica, Silicosis, and Lung Cancer in Diatomite Workers.
PB97207120

Publication Date	1996
Personal Author	Checkoway, H.; Heyer, N. J.; Seixas, N. S.; Welp, E. A. E.; Demers, P. A.; Hughes, J. M.; Weill, H.
Page Count	56
Abstract	The project served to update a cohort mortality study of workers exposed to crystalline silica (14808607), primarily as cristobalite (14464461). Exposure occurred during the mining and processing of diatomaceous-earth in two facilities located in California. There were 2,961 workers in the cohort who had at least 12 months of cumulative service at either facility. This update extended an earlier study by 7 years. Mortality was followed up for 1942 through 1994. Chest radiographs were obtained for 2,520 workers. As expected, radiographcally determined silicosis was strongly related to cumulative exposure to crystalline silica. Compared to national rates, mortality rates from both nonmalignant respiratory disease and lung cancer were elevated among these workers. A strong dose response association was noted for cumulative exposure to crystalline silica and mortality from nonmalignant respiratory diseases. Lung cancer mortality was also associated with cumulative exposure to crystalline silica, but the association was not as strong as that from nonmalignant respiratory disease. Confounding by either smoking or by occupational asbestos (1332214) exposure was not likely to account for the observed exposure/response relations with nonmalignant respiratory disease and lung cancer mortality.
Keywords	Occupational safety and health Silica dusts Lung cancer Pulmonary system disorders Morality Risk factors Epidemiology Respiratory system disorders Mining industry
Source Agency	National Institute for Occupational Safety and Health
Corporate Authors	Washington Univ., Seattle. Dept. of Environmental Health.; British Columbia Univ., Vancouver. Occupational Hygiene Programme.; National Inst. for Occupational Safety and Health, Cincinnati, OH.; Tulane Univ. Medical Center, New Orleans, LA. Section of Environmental
Supplemental Notes	Prepared in cooperation with British Columbia Univ., Vancouver. Occupational Hygiene Programme. and Tulane Univ. Medical Center, New Orleans, LA. Section of Environmental Medicine. Sponsored by National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
Title Note	Final rept.
NTIS Issue Number	199724