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Details

Metal Fume Fever.

PB97206379

Publication Date	1996
Personal Author	Beckett, W. S.; Chen, L. C.; Cosma, G.; Fine, J.; Garte, S.; Gordon, T.; Kinney, P.; Sparer, J.
Page Count	44
Abstract	The acute response to zinc-oxide (1314132) fumes in naive human subjects and galvanized sheet metal workers was investigated. Of 12 naive subjects, ten experienced a mild fever after a 2 hour exposure to zinc-oxide fume at 5mg/m3 (the OSHA permissible exposure limit) or 2.5mg/m3. Metal fume fever symptoms were significantly increased 6 and 9 hours after a 5mg/m3 exposure. The most common symptoms were fatigue, muscle ache, and cough. Elevated white blood cell counts were also seen. Those who experienced mild symptoms and fever developed tolerance of these effects with repeated exposures on subsequent days. Sheet metal workers with ongoing low level exposure showed tolerance to exposure at 5mg/m3. However, zinc-oxide exposure in these individuals induced elevated levels of interleukin-6 in the blood. The findings demonstrated that mild symptoms and fever can occur in previously unexposed men and women several hours after they breathe ultrafine zinc-oxide fumes for only 2 hours at the 5.0mg/m3 level. This occurred in a high proportion of healthy and normal individuals.
Keywords	Occupational safety and health Pulmonary system disorders Metalworking industry Indoor air pollution Metal oxides Respiratory system disorders Zinc oxide Exposures Metal fume fever
Source Agency	National Institute for Occupational Safety and Health
Corporate Authors	Yale Univ., New Haven, CT. School of Medicine.; Columbia Univ., New York.; Colorado State Univ., Fort Collins.; New York Univ., NY.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Supplemental Notes	Prepared in cooperation with New York Univ., NY., Colorado State Univ., Fort Collins. and Columbia Univ., New York. Sponsored by National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
Title Note	Final rept.
NTIS Issue Number	199724

Metal Fume Fever.

Metal Fume Fever.
PB97206379

Publication Date	1996
Personal Author	Beckett, W. S.; Chen, L. C.; Cosma, G.; Fine, J.; Garte, S.; Gordon, T.; Kinney, P.; Sparer, J.
Page Count	44
Abstract	The acute response to zinc-oxide (1314132) fumes in naive human subjects and galvanized sheet metal workers was investigated. Of 12 naive subjects, ten experienced a mild fever after a 2 hour exposure to zinc-oxide fume at 5mg/m3 (the OSHA permissible exposure limit) or 2.5mg/m3. Metal fume fever symptoms were significantly increased 6 and 9 hours after a 5mg/m3 exposure. The most common symptoms were fatigue, muscle ache, and cough. Elevated white blood cell counts were also seen. Those who experienced mild symptoms and fever developed tolerance of these effects with repeated exposures on subsequent days. Sheet metal workers with ongoing low level exposure showed tolerance to exposure at 5mg/m3. However, zinc-oxide exposure in these individuals induced elevated levels of interleukin-6 in the blood. The findings demonstrated that mild symptoms and fever can occur in previously unexposed men and women several hours after they breathe ultrafine zinc-oxide fumes for only 2 hours at the 5.0mg/m3 level. This occurred in a high proportion of healthy and normal individuals.
Keywords	Occupational safety and health Pulmonary system disorders Metalworking industry Indoor air pollution Metal oxides Respiratory system disorders Zinc oxide Exposures Metal fume fever
Source Agency	National Institute for Occupational Safety and Health
Corporate Authors	Yale Univ., New Haven, CT. School of Medicine.; Columbia Univ., New York.; Colorado State Univ., Fort Collins.; New York Univ., NY.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Supplemental Notes	Prepared in cooperation with New York Univ., NY., Colorado State Univ., Fort Collins. and Columbia Univ., New York. Sponsored by National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
Title Note	Final rept.
NTIS Issue Number	199724