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Pulmonary Effects of Machining Fluid Aerosols. Final Performance Report.

PB97206353

Publication Date	1997
Personal Author	Gordon, T.
Page Count	23
Abstract	The relative toxicity of three major classes of machining fluids (soluble, synthetic and semisynthetic) was compared in an animal model of pulmonary injyry and inflammation. Significant differences in toxicity were noted in guinea-pigs after a single 3 hour exposure suggesting that various types of machining fluids may have inherent differences in toxicity in the workplace. Greater toxicity was noted in guinea-pigs exposed for 3 hours to used machining fluid aerosols compared to aerosols of unused fluids. Physicochemical properties of machining fluids were also found to contribute to adverse pulmonary effects. Little to no pulmonary injury or inflammation was noted in guinea-pigs exposed to 5mg/m3 used machining fluid aerosols for 30 days. Three daily exposures of rats to 20mg/m3 used machining fluid aerosols produced a significant increase in stored mucosubstances in the epithelial lining of the intrapulmonary airways and the nasal septum. These findings suggest that irritant components of machining fluids can contribute to the increase in sputum and chronic bronchitis reported for workers exposed to machining fluid aerosols.
Keywords	Toxicity Machining fluids Occupational safety and health Aerosols Laboratory animals Inhalation Cutting oils Pulmonary system disorders Respiratory system disorders
Source Agency	National Institute for Occupational Safety and Health
Corporate Authors	New York Univ. Medical Center, NY. Dept. of Environmental Medicine.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Supplemental Notes	Sponsored by National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
NTIS Issue Number	199724

Pulmonary Effects of Machining Fluid Aerosols. Final Performance Report.

Pulmonary Effects of Machining Fluid Aerosols. Final Performance Report.
PB97206353

Publication Date	1997
Personal Author	Gordon, T.
Page Count	23
Abstract	The relative toxicity of three major classes of machining fluids (soluble, synthetic and semisynthetic) was compared in an animal model of pulmonary injyry and inflammation. Significant differences in toxicity were noted in guinea-pigs after a single 3 hour exposure suggesting that various types of machining fluids may have inherent differences in toxicity in the workplace. Greater toxicity was noted in guinea-pigs exposed for 3 hours to used machining fluid aerosols compared to aerosols of unused fluids. Physicochemical properties of machining fluids were also found to contribute to adverse pulmonary effects. Little to no pulmonary injury or inflammation was noted in guinea-pigs exposed to 5mg/m3 used machining fluid aerosols for 30 days. Three daily exposures of rats to 20mg/m3 used machining fluid aerosols produced a significant increase in stored mucosubstances in the epithelial lining of the intrapulmonary airways and the nasal septum. These findings suggest that irritant components of machining fluids can contribute to the increase in sputum and chronic bronchitis reported for workers exposed to machining fluid aerosols.
Keywords	Toxicity Machining fluids Occupational safety and health Aerosols Laboratory animals Inhalation Cutting oils Pulmonary system disorders Respiratory system disorders
Source Agency	National Institute for Occupational Safety and Health
Corporate Authors	New York Univ. Medical Center, NY. Dept. of Environmental Medicine.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Supplemental Notes	Sponsored by National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
NTIS Issue Number	199724