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NTP Summary Report on the Metabolism, Disposition, and Toxicity of 1,4-Butanediol (CAS No. 110-63-4).

PB97108161

Publication Date	1996
Personal Author	Irwin, R. D.
Page Count	46
Abstract	1,4-Butanediol is an industrial chemical used in the manufacture of other organic chemicals. It was nominated by the National Cancer Institute and selected for evaluation by the NTP because of high production volume, the potential for worker exposure, the lack of adequate toxicological characterization, and the lack of evaluation for carcinogenic potential. As documented in the scientific literature, 1,4-butanediol is rapidly absorbed and metabolized to gamma-hydroxybutyric acid in animals and humans. A metabolism and disposition study conducted in F344/N rats by the NTP confirmed the rapid and extensive conversion of 1/(14C)-1,4-butanediol to 14CO2. Because of this rapid and extensive conversion, the toxicological profile of 1,4-butanediol reflects that of gamma-hydroxybutyric acid. gamma-Hydroxybutyric acid is a naturally occurring chemical found in the brain and peripheral tissues which is converted to succinate and processed through the tricarboxylic acid cycle.
Keywords	Toxicity Chemical properties Physical properties Rats Laboratory animals Metabolism Disposition Pharmacology Carcinogenicity Genetics Butanediols 1 4-Butanediol
Source Agency	National Institute of Environmental Health Sciences
NTIS Subject Category	57Y - Toxicology 57S - Physiology 68G - Environmental Health & Safety
Corporate Authors	National Toxicology Program, Research Triangle Park, NC.
Document Type	Technical Report
Title Note	Toxicity rept. series.
NTIS Issue Number	199701

NTP Summary Report on the Metabolism, Disposition, and Toxicity of 1,4-Butanediol (CAS No. 110-63-4).

NTP Summary Report on the Metabolism, Disposition, and Toxicity of 1,4-Butanediol (CAS No. 110-63-4).
PB97108161

Publication Date	1996
Personal Author	Irwin, R. D.
Page Count	46
Abstract	1,4-Butanediol is an industrial chemical used in the manufacture of other organic chemicals. It was nominated by the National Cancer Institute and selected for evaluation by the NTP because of high production volume, the potential for worker exposure, the lack of adequate toxicological characterization, and the lack of evaluation for carcinogenic potential. As documented in the scientific literature, 1,4-butanediol is rapidly absorbed and metabolized to gamma-hydroxybutyric acid in animals and humans. A metabolism and disposition study conducted in F344/N rats by the NTP confirmed the rapid and extensive conversion of 1/(14C)-1,4-butanediol to 14CO2. Because of this rapid and extensive conversion, the toxicological profile of 1,4-butanediol reflects that of gamma-hydroxybutyric acid. gamma-Hydroxybutyric acid is a naturally occurring chemical found in the brain and peripheral tissues which is converted to succinate and processed through the tricarboxylic acid cycle.
Keywords	Toxicity Chemical properties Physical properties Rats Laboratory animals Metabolism Disposition Pharmacology Carcinogenicity Genetics Butanediols 1 4-Butanediol
Source Agency	National Institute of Environmental Health Sciences
NTIS Subject Category	57Y - Toxicology 57S - Physiology 68G - Environmental Health & Safety
Corporate Authors	National Toxicology Program, Research Triangle Park, NC.
Document Type	Technical Report
Title Note	Toxicity rept. series.
NTIS Issue Number	199701