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Vascular Effects of Chelation in Lead-Exposed Workers.

PB97105654

Publication Date	1995
Personal Author	Kosnett, M. J.
Page Count	48
Abstract	The effect of chelation in lead (7439921) exposed, hypertensive workers on vascular reactivity as monitored by changes in blood pressure response to infused norepinephrine was investigated. The three black workers and one Caucasian worker who had been exposed to lead underwent inpatient dietary equilibration, and were given a stepped dose infusion of norepinephrine just before and just after each experimental intervention of EDTA chelation or placebo. Each subject also underwent a noninvasive assessment of bone lead concentration. There was no significant effect of chelation on vascular reactivity in these lead exposed, hypertensive workers. K-X-ray fluorescence measurements of lead in bone were made in 31 male workers with known lead exposure, and a chelation challenge test was performed in 28. The K-X-ray fluorescence measurement was found to be a better marker of long term lead exposure than the chelation test. In a group of 101 individuals with only limited occupational lead exposure, the age and sex related increases in bone lead concentration were consistent with the kinetics of bone turnover and secular trends in lead exposure.
Keywords	Lead(Metal) Chelation Occupational safety and health Lead poisoning Biological monitoring Occupational exposure Cardiovascular system disorders
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57U - Public Health & Industrial Medicine 68G - Environmental Health & Safety 94H - Industrial Safety Engineering
Corporate Authors	California Univ., Davis. Div. of Occupational and Environmental Medicine.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Supplemental Notes	Sponsored by National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
Title Note	Final rept. 30 Sep 91-30 Mar 95.
NTIS Issue Number	199701

Vascular Effects of Chelation in Lead-Exposed Workers.

Vascular Effects of Chelation in Lead-Exposed Workers.
PB97105654

Publication Date	1995
Personal Author	Kosnett, M. J.
Page Count	48
Abstract	The effect of chelation in lead (7439921) exposed, hypertensive workers on vascular reactivity as monitored by changes in blood pressure response to infused norepinephrine was investigated. The three black workers and one Caucasian worker who had been exposed to lead underwent inpatient dietary equilibration, and were given a stepped dose infusion of norepinephrine just before and just after each experimental intervention of EDTA chelation or placebo. Each subject also underwent a noninvasive assessment of bone lead concentration. There was no significant effect of chelation on vascular reactivity in these lead exposed, hypertensive workers. K-X-ray fluorescence measurements of lead in bone were made in 31 male workers with known lead exposure, and a chelation challenge test was performed in 28. The K-X-ray fluorescence measurement was found to be a better marker of long term lead exposure than the chelation test. In a group of 101 individuals with only limited occupational lead exposure, the age and sex related increases in bone lead concentration were consistent with the kinetics of bone turnover and secular trends in lead exposure.
Keywords	Lead(Metal) Chelation Occupational safety and health Lead poisoning Biological monitoring Occupational exposure Cardiovascular system disorders
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57U - Public Health & Industrial Medicine 68G - Environmental Health & Safety 94H - Industrial Safety Engineering
Corporate Authors	California Univ., Davis. Div. of Occupational and Environmental Medicine.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Supplemental Notes	Sponsored by National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
Title Note	Final rept. 30 Sep 91-30 Mar 95.
NTIS Issue Number	199701