| Publication Date |
1996 |
| Page Count |
288 |
| Abstract |
The potential reproductive toxicity of caffeine in Sprague-Dawley rats was evaluated using the Reproductive Assessment by Continuous Breeding (RACB) protocol. Based on decreased body weights and feed consumption, increased water consumption, and mortality noted during Task 1, dose levels for the continuous breeding phase for this study were set at 12.5, 25, and 50 mg/kg. Male and female Sprague-Dawley rats were exposed to caffeine in deionized water by oral gavage at a dose volume of 5 ml/kg. Individual dose volumes were adjusted weekly. During 16 weeks of cohabitation, live pup weight adjusted for litter size was decreased by 7, 7 and 8% in the 12.5, 25, and 50 mg/kg dose groups, respectively. No differences were observed in other reproductive endpoints. A crossover mating trial (Task 3) revealed no changes on male or female fertility or in pup weight. Reproductive parameters were comparable between dose groups when naive males were mated with control or 50 mg/kg females and when naive females were mated with control or 50 mg/kg males. |
| Keywords |
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| Source Agency |
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| NTIS Subject Category |
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| Corporate Authors |
National Toxicology Program, Research Triangle Park, NC.; Public Health Service, Rockville, MD.; R.O.W. Sciences, Inc., Gaithersburg, MD. |
| Supplemental Notes |
Prepared in cooperation with R.O.W. Sciences, Inc., Gaithersburg, MD. Sponsored by Public Health Service, Rockville, MD. |
| Document Type |
Technical Report |
| Title Note |
Technical rept. |
| NTIS Issue Number |
199624 |
| Contract Number |
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