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Sodium Bromate: Short Term Reproductive and Developmental Toxicity Study When Administered to Sprague-Dawley Rats in the Drinking Water. Final Report.

PB96190640

Publication Date	1996
Personal Author	Wolfe, G. W.; Kaiser, L.
Page Count	316
Abstract	The potential toxicity of sodium bromate (CAS No. 7789-38-0) was evaluated using a short-term reproductive and developmental toxicity screen. This study design was selected to identify the process (development; female reproduction; male reproduction; various somatic organs/processes) that is the most sensitive to sodium bromate exposure. A dose range-finding study was conducted at concentrations of 0, 250, 500, 1000, and 2000 ppm in order to select concentrations for the 35-day study. Based on dose-related body weight reductions and decreased feed and water consumption, the concentrations for the 35-day study were selected to be 0, 25, 80, and 250 ppm. For the main study, Sprague-Dawley rats were administered sodium bromate at these concentrations in the drinking water over a 35-day period. One group of male rats (10 per group) and two groups of female rats designated as Group A (peri-conception, 10 per group) and Group B (gestational exposure, 13 per group) were used at each dose level. Control animals received deionized water, the vehicle.
Keywords	Toxicity Sodium bromate Reproduction(Biology) Rats Laboratory animals Drinking water Dosage Concentrations CAS Registry No: 7789-38-0
Source Agency	National Institute of Environmental Health Sciences
NTIS Subject Category	57Y - Toxicology
Corporate Authors	R.O.W. Sciences, Inc., Gaithersburg, MD.; National Toxicology Program, Research Triangle Park, NC.
Supplemental Notes	Sponsored by National Toxicology Program, Research Triangle Park, NC.
Document Type	Technical Report
Title Note	Final rept.
NTIS Issue Number	199619
Contract Number	NIEHS-N01-ES-15323

Sodium Bromate: Short Term Reproductive and Developmental Toxicity Study When Administered to Sprague-Dawley Rats in the Drinking Water. Final Report.

Sodium Bromate: Short Term Reproductive and Developmental Toxicity Study When Administered to Sprague-Dawley Rats in the Drinking Water. Final Report.
PB96190640

Publication Date	1996
Personal Author	Wolfe, G. W.; Kaiser, L.
Page Count	316
Abstract	The potential toxicity of sodium bromate (CAS No. 7789-38-0) was evaluated using a short-term reproductive and developmental toxicity screen. This study design was selected to identify the process (development; female reproduction; male reproduction; various somatic organs/processes) that is the most sensitive to sodium bromate exposure. A dose range-finding study was conducted at concentrations of 0, 250, 500, 1000, and 2000 ppm in order to select concentrations for the 35-day study. Based on dose-related body weight reductions and decreased feed and water consumption, the concentrations for the 35-day study were selected to be 0, 25, 80, and 250 ppm. For the main study, Sprague-Dawley rats were administered sodium bromate at these concentrations in the drinking water over a 35-day period. One group of male rats (10 per group) and two groups of female rats designated as Group A (peri-conception, 10 per group) and Group B (gestational exposure, 13 per group) were used at each dose level. Control animals received deionized water, the vehicle.
Keywords	Toxicity Sodium bromate Reproduction(Biology) Rats Laboratory animals Drinking water Dosage Concentrations CAS Registry No: 7789-38-0
Source Agency	National Institute of Environmental Health Sciences
NTIS Subject Category	57Y - Toxicology
Corporate Authors	R.O.W. Sciences, Inc., Gaithersburg, MD.; National Toxicology Program, Research Triangle Park, NC.
Supplemental Notes	Sponsored by National Toxicology Program, Research Triangle Park, NC.
Document Type	Technical Report
Title Note	Final rept.
NTIS Issue Number	199619
Contract Number	NIEHS-N01-ES-15323