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Influence of Particulates on Occupational Lung Disease.

PB95267878

Publication Date	1994
Personal Author	Warshawsky, D.; Radike, M.; Talaska, G.; Miller, M.; Wilson, L.
Page Count	44
Abstract	The ability of alveolar macrophages (AM) to phagocytize uncoated and benzo(a)pyrene (50328) (BaP) coated particulates was investigated. AM from male Syrian-golden-hamsters and Sprague-Dawley-rats were used. Particulates included crystalline-silica (14808607); precipitated, gelled, and fumed amorphous-silica (7631869); ferric-oxide (1309371); and aluminum-oxide (1344281). All forms of amorphous silica had smaller particle sizes and were cytotoxic, suggesting that more of the dose for the amorphous silicas having more silanol groups being more cytotoxic. These same properties were important in the metabolic activation of BaP by AM. At a similar dose of BaP and particle, all of the BaP coated particles produced more BaP dihydrodiols than BaP alone. AM exposed to particles coated with BaP responded differently than either BaP or particles alone at noncytotoxic doses, For metabolism, DNA binding and cytotoxicity parameters, the surface area of the particle appeared to play a major role.
Keywords	Occupational safety and health Particulates Air pollution effects(Human) Lung diseases Aerosols Airborne wastes Respiratory system disorders Cell cultures Polycyclic aromatic hydrocarbons
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	68A - Air Pollution & Control 68G - Environmental Health & Safety 57U - Public Health & Industrial Medicine
Corporate Authors	Cincinnati Univ., OH. Dept. of Environmental Health.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Supplemental Notes	Sponsored by National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
NTIS Issue Number	199523

Influence of Particulates on Occupational Lung Disease.

Influence of Particulates on Occupational Lung Disease.
PB95267878

Publication Date	1994
Personal Author	Warshawsky, D.; Radike, M.; Talaska, G.; Miller, M.; Wilson, L.
Page Count	44
Abstract	The ability of alveolar macrophages (AM) to phagocytize uncoated and benzo(a)pyrene (50328) (BaP) coated particulates was investigated. AM from male Syrian-golden-hamsters and Sprague-Dawley-rats were used. Particulates included crystalline-silica (14808607); precipitated, gelled, and fumed amorphous-silica (7631869); ferric-oxide (1309371); and aluminum-oxide (1344281). All forms of amorphous silica had smaller particle sizes and were cytotoxic, suggesting that more of the dose for the amorphous silicas having more silanol groups being more cytotoxic. These same properties were important in the metabolic activation of BaP by AM. At a similar dose of BaP and particle, all of the BaP coated particles produced more BaP dihydrodiols than BaP alone. AM exposed to particles coated with BaP responded differently than either BaP or particles alone at noncytotoxic doses, For metabolism, DNA binding and cytotoxicity parameters, the surface area of the particle appeared to play a major role.
Keywords	Occupational safety and health Particulates Air pollution effects(Human) Lung diseases Aerosols Airborne wastes Respiratory system disorders Cell cultures Polycyclic aromatic hydrocarbons
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	68A - Air Pollution & Control 68G - Environmental Health & Safety 57U - Public Health & Industrial Medicine
Corporate Authors	Cincinnati Univ., OH. Dept. of Environmental Health.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Supplemental Notes	Sponsored by National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
NTIS Issue Number	199523