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Activation of H-ras Oncogene by Drinking Water Disinfectant By-Products.


PB95200515

Publication Date 1994
Personal Author Velazquez, S. F.
Page Count 46
Abstract The frequency and spectrum of H-ras oncogene activation by the water disinfection by products 2-chloroacetaldehyde (107200) (CAA), chloral hydrate (302170) (CH), and dichloroacetic acid (79436) (DCA) was investigated in the livers of male B6C3F1-mice. Mice had been administered high doses of these chemicals over a 2 year period. No mutations were noted in the H-ras oncogene in any normal liver tissue samples taken from mice with hepatocellular carcinomas. A higher frequency of H-ras mutation was found for liver tumors in mice administered DCA. The authors conclude that the induction of the hepatocellular carcinomas by CAA does not involve the activation of the H-ras oncogene. The authors suggest that while DCA is most likely not directly causing these H-ras mutations, the proliferative action of DCA on the liver may be preferentially promoting cells containing ras mutations.
Keywords
  • Oncogene proteins
  • Drinking water
  • Disinfection
  • Chlorine organic compounds
  • Liver neoplasms
  • Mutagenesis
  • Exposure
  • Mice
  • Activation
  • Acyclic aldehydes
  • Dose-response relationships
  • Biological effects
  • Cancer
  • Ras genes
  • Ras proteins
  • Disinfectants
  • Water pollution effects(Animals)
  • H-ras oncogene
  • H-ras genes
  • Disinfectant by-products
  • CAA(2-Chloroacetaldehyde)
  • CH(Chloral hydrate)
  • DCA(Dichloroacetic acid)
  • CAS 107200
  • CAS 302170
  • CAS 79436
Source Agency
  • National Institute for Occupational Safety and Health
NTIS Subject Category
  • 57Y - Toxicology
  • 57U - Public Health & Industrial Medicine
  • 68G - Environmental Health & Safety
  • 68D - Water Pollution & Control
Corporate Authors Cincinnati Univ., OH. Dept. of Environmental Health.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Supplemental Notes Sponsored by National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type Technical Report
NTIS Issue Number 199514
Activation of H-ras Oncogene by Drinking Water Disinfectant By-Products.
Activation of H-ras Oncogene by Drinking Water Disinfectant By-Products.
PB95200515

  • Oncogene proteins
  • Drinking water
  • Disinfection
  • Chlorine organic compounds
  • Liver neoplasms
  • Mutagenesis
  • Exposure
  • Mice
  • Activation
  • Acyclic aldehydes
  • Dose-response relationships
  • Biological effects
  • Cancer
  • Ras genes
  • Ras proteins
  • Disinfectants
  • Water pollution effects(Animals)
  • H-ras oncogene
  • H-ras genes
  • Disinfectant by-products
  • CAA(2-Chloroacetaldehyde)
  • CH(Chloral hydrate)
  • DCA(Dichloroacetic acid)
  • CAS 107200
  • CAS 302170
  • CAS 79436
  • National Institute for Occupational Safety and Health
  • 57Y - Toxicology
  • 57U - Public Health & Industrial Medicine
  • 68G - Environmental Health & Safety
  • 68D - Water Pollution & Control
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