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Activation of H-ras Oncogene by Drinking Water Disinfectant By-Products.

PB95200515

Publication Date	1994
Personal Author	Velazquez, S. F.
Page Count	46
Abstract	The frequency and spectrum of H-ras oncogene activation by the water disinfection by products 2-chloroacetaldehyde (107200) (CAA), chloral hydrate (302170) (CH), and dichloroacetic acid (79436) (DCA) was investigated in the livers of male B6C3F1-mice. Mice had been administered high doses of these chemicals over a 2 year period. No mutations were noted in the H-ras oncogene in any normal liver tissue samples taken from mice with hepatocellular carcinomas. A higher frequency of H-ras mutation was found for liver tumors in mice administered DCA. The authors conclude that the induction of the hepatocellular carcinomas by CAA does not involve the activation of the H-ras oncogene. The authors suggest that while DCA is most likely not directly causing these H-ras mutations, the proliferative action of DCA on the liver may be preferentially promoting cells containing ras mutations.
Keywords	Oncogene proteins Drinking water Disinfection Chlorine organic compounds Liver neoplasms Mutagenesis Exposure Mice Activation Acyclic aldehydes Dose-response relationships Biological effects Cancer Ras genes Ras proteins Disinfectants Water pollution effects(Animals) H-ras oncogene H-ras genes Disinfectant by-products CAA(2-Chloroacetaldehyde) CH(Chloral hydrate) DCA(Dichloroacetic acid) CAS 107200 CAS 302170 CAS 79436
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57Y - Toxicology 57U - Public Health & Industrial Medicine 68G - Environmental Health & Safety 68D - Water Pollution & Control
Corporate Authors	Cincinnati Univ., OH. Dept. of Environmental Health.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Supplemental Notes	Sponsored by National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
NTIS Issue Number	199514

Activation of H-ras Oncogene by Drinking Water Disinfectant By-Products.

Activation of H-ras Oncogene by Drinking Water Disinfectant By-Products.
PB95200515

Publication Date	1994
Personal Author	Velazquez, S. F.
Page Count	46
Abstract	The frequency and spectrum of H-ras oncogene activation by the water disinfection by products 2-chloroacetaldehyde (107200) (CAA), chloral hydrate (302170) (CH), and dichloroacetic acid (79436) (DCA) was investigated in the livers of male B6C3F1-mice. Mice had been administered high doses of these chemicals over a 2 year period. No mutations were noted in the H-ras oncogene in any normal liver tissue samples taken from mice with hepatocellular carcinomas. A higher frequency of H-ras mutation was found for liver tumors in mice administered DCA. The authors conclude that the induction of the hepatocellular carcinomas by CAA does not involve the activation of the H-ras oncogene. The authors suggest that while DCA is most likely not directly causing these H-ras mutations, the proliferative action of DCA on the liver may be preferentially promoting cells containing ras mutations.
Keywords	Oncogene proteins Drinking water Disinfection Chlorine organic compounds Liver neoplasms Mutagenesis Exposure Mice Activation Acyclic aldehydes Dose-response relationships Biological effects Cancer Ras genes Ras proteins Disinfectants Water pollution effects(Animals) H-ras oncogene H-ras genes Disinfectant by-products CAA(2-Chloroacetaldehyde) CH(Chloral hydrate) DCA(Dichloroacetic acid) CAS 107200 CAS 302170 CAS 79436
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57Y - Toxicology 57U - Public Health & Industrial Medicine 68G - Environmental Health & Safety 68D - Water Pollution & Control
Corporate Authors	Cincinnati Univ., OH. Dept. of Environmental Health.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Supplemental Notes	Sponsored by National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
NTIS Issue Number	199514