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Industrial Hygiene Report Walk-Through Survey, Mallinckrodt Specialty Chemicals Company, Chesterfield, Missouri, January 19, 1993.

PB94164159

Publication Date	1993
Personal Author	Boeniger, M. F.; Alderfer, R.
Page Count	10
Abstract	A walk through survey was conducted at the Mallinckrodt Specialty Chemicals Company (SIC-2833) located in Chesterfield, Missouri to assess the feasibility of conducting studies on the immunotoxic effects of chemicals at this facility. The opiate refining facility at the site had been in constant operation for about 100 years. Morphine (57272), codeine (76573), thebaine (115377), noscapine (128621) and papaverine (58742) were produced. A total of 66 chemical operators, 20 salaried personnel and additional support staff were involved in the production of the opiates. Nine full time safety and health professionals were employed by the company. Urine samples were collected at scheduled periodic medical examinations and tested for opiates. Ventilation controls appeared minimal, but surfaces were free of accumulated dust. Personnel records appeared to be inadequate for retrospective mortality or mobidity studies. Because of incomplete or inconsistent data collection at various sites, it was difficult to determine if the findings at this site were comparable to those at other facilities. The authors conclude that additional exposure information may be needed to determine the feasibility of conducting a study at this facility.
Keywords	Industrial hygiene Environmental surveys Occupational safety and health Drug industry Opium aklaiods Occupational exposure Narcotics Ventilation Epidemiology Papaverine Urinalysis Morphine Codeine Thebaine Noscapine Chesterfield(Missouri) EPA Region 7 CAS 76-57-3 CAS 115-37-7 CAS 128-62-1 CAS 57-27-2 CAS 58-74-2 SIC 2833
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57U - Public Health & Industrial Medicine 57Q - Pharmacology & Pharmacological Chemistry 94D - Job Environment 68G - Environmental Health & Safety
Corporate Authors	National Inst. for Occupational Safety and Health, Cincinnati, OH. Industrywide Studies Branch.
Document Type	Technical Report
Title Note	Final rept.
NTIS Issue Number	199415

Industrial Hygiene Report Walk-Through Survey, Mallinckrodt Specialty Chemicals Company, Chesterfield, Missouri, January 19, 1993.

Industrial Hygiene Report Walk-Through Survey, Mallinckrodt Specialty Chemicals Company, Chesterfield, Missouri, January 19, 1993.
PB94164159

Publication Date	1993
Personal Author	Boeniger, M. F.; Alderfer, R.
Page Count	10
Abstract	A walk through survey was conducted at the Mallinckrodt Specialty Chemicals Company (SIC-2833) located in Chesterfield, Missouri to assess the feasibility of conducting studies on the immunotoxic effects of chemicals at this facility. The opiate refining facility at the site had been in constant operation for about 100 years. Morphine (57272), codeine (76573), thebaine (115377), noscapine (128621) and papaverine (58742) were produced. A total of 66 chemical operators, 20 salaried personnel and additional support staff were involved in the production of the opiates. Nine full time safety and health professionals were employed by the company. Urine samples were collected at scheduled periodic medical examinations and tested for opiates. Ventilation controls appeared minimal, but surfaces were free of accumulated dust. Personnel records appeared to be inadequate for retrospective mortality or mobidity studies. Because of incomplete or inconsistent data collection at various sites, it was difficult to determine if the findings at this site were comparable to those at other facilities. The authors conclude that additional exposure information may be needed to determine the feasibility of conducting a study at this facility.
Keywords	Industrial hygiene Environmental surveys Occupational safety and health Drug industry Opium aklaiods Occupational exposure Narcotics Ventilation Epidemiology Papaverine Urinalysis Morphine Codeine Thebaine Noscapine Chesterfield(Missouri) EPA Region 7 CAS 76-57-3 CAS 115-37-7 CAS 128-62-1 CAS 57-27-2 CAS 58-74-2 SIC 2833
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57U - Public Health & Industrial Medicine 57Q - Pharmacology & Pharmacological Chemistry 94D - Job Environment 68G - Environmental Health & Safety
Corporate Authors	National Inst. for Occupational Safety and Health, Cincinnati, OH. Industrywide Studies Branch.
Document Type	Technical Report
Title Note	Final rept.
NTIS Issue Number	199415