Publication Date |
1993 |
Personal Author |
Matanoski, G. M.; Correa-Villasenor, A.; Francis, M.; Elliott, E. A. |
Page Count |
34 |
Abstract |
A nested case/control study was conducted of gastrointestinal cancer in male workers from eight styrene-butadiene polymer manufacturing facilities in the United States and Canada to determine whether there was any association with exposures to styrene and butadiene. A study on the association between hematologic neoplasms and exposure to butadiene and styrene was reexamined using different criteria for matching and exposure. Exposure levels for each job in the industry were developed, based on area and personal monitoring. The risk of lymphohematopoietic cancers was increased in the workers who had increased exposure to butadiene. Even using different methodologies such as choosing different types of controls, the risk of leukemia among these workers remained high. Among the leukemia cases, there was a higher than expected proportion of acute lymphocytic leukemia. Some of the odds ratios were high for butadiene and styrene associated with esophageal cancers, but the findings were not statistically significant. Also, not significant was a suggestive trend for increasing odds ratios with increasing butadiene exposure for colorectal cancers. When short term workers were included, there was an increase in the all cause mortality, but no increase in standardized mortality ratios for cancer or circulatory diseases. Long term workers had higher risks for cancers of interest in this study than short term workers. |
Keywords |
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Source Agency |
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NTIS Subject Category |
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Corporate Authors |
Johns Hopkins Univ., Baltimore, MD. Dept. of Epidemiology.; National Inst. for Occupational Safety and Health, Cincinnati, OH. |
Supplemental Notes |
Sponsored by National Inst. for Occupational Safety and Health, Cincinnati, OH. |
Document Type |
Technical Report |
Title Note |
Final rept. |
NTIS Issue Number |
199324 |