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Evaluation of the Potential Carcinogenicity of Amitrole (61-82-5).

PB93181659

Publication Date	1988
Page Count	20
Abstract	Amitrole is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment. Evidence on potential carcinogenicity from animal studies is 'sufficient,' and the evidence from human studies is 'inadequate.' The potency factor (F) for amitrole is estimated to be 3.30/(mg/kg/day), placing it in potency group 2 according to the CAG's methodology for evaluating potential carcinogens. Combining the weight-of-evidence group and the potency group, amitrole is assigned a 'MEDIUM' hazard ranking for the purposes of RQ adjustment.
Keywords	Carcinogens Toxicity Amitrole Humans Animals Dose-response relationships Carcinogenicity tests CAS 61-82-5
Source Agency	Environmental Protection Agency Office of Research and Development
NTIS Subject Category	57Y - Toxicology
Corporate Authors	Syracuse Research Corp., NY.; Environmental Monitoring and Services, Inc., Washington, DC.; Environmental Protection Agency, Washington, DC. Office of Health and
Supplemental Notes	See also PB-223 159. Prepared in cooperation with Environmental Monitoring and Services, Inc., Washington, DC. Sponsored by Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment.
Document Type	Technical Report
Title Note	Final rept.
NTIS Issue Number	199314
Contract Number	EPA-68-03-3112 EPA-68-03-3182

Evaluation of the Potential Carcinogenicity of Amitrole (61-82-5).

Evaluation of the Potential Carcinogenicity of Amitrole (61-82-5).
PB93181659

Publication Date	1988
Page Count	20
Abstract	Amitrole is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment. Evidence on potential carcinogenicity from animal studies is 'sufficient,' and the evidence from human studies is 'inadequate.' The potency factor (F) for amitrole is estimated to be 3.30/(mg/kg/day), placing it in potency group 2 according to the CAG's methodology for evaluating potential carcinogens. Combining the weight-of-evidence group and the potency group, amitrole is assigned a 'MEDIUM' hazard ranking for the purposes of RQ adjustment.
Keywords	Carcinogens Toxicity Amitrole Humans Animals Dose-response relationships Carcinogenicity tests CAS 61-82-5
Source Agency	Environmental Protection Agency Office of Research and Development
NTIS Subject Category	57Y - Toxicology
Corporate Authors	Syracuse Research Corp., NY.; Environmental Monitoring and Services, Inc., Washington, DC.; Environmental Protection Agency, Washington, DC. Office of Health and
Supplemental Notes	See also PB-223 159. Prepared in cooperation with Environmental Monitoring and Services, Inc., Washington, DC. Sponsored by Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment.
Document Type	Technical Report
Title Note	Final rept.
NTIS Issue Number	199314
Contract Number	EPA-68-03-3112 EPA-68-03-3182