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Evaluation of the Potential Carcinogenicity of Amitrole (61-82-5).


PB93181659

Publication Date 1988
Page Count 20
Abstract Amitrole is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment. Evidence on potential carcinogenicity from animal studies is 'sufficient,' and the evidence from human studies is 'inadequate.' The potency factor (F) for amitrole is estimated to be 3.30/(mg/kg/day), placing it in potency group 2 according to the CAG's methodology for evaluating potential carcinogens. Combining the weight-of-evidence group and the potency group, amitrole is assigned a 'MEDIUM' hazard ranking for the purposes of RQ adjustment.
Keywords
  • Carcinogens
  • Toxicity
  • Amitrole
  • Humans
  • Animals
  • Dose-response relationships
  • Carcinogenicity tests
  • CAS 61-82-5
Source Agency
  • Environmental Protection Agency Office of Research and Development
NTIS Subject Category
  • 57Y - Toxicology
Corporate Authors Syracuse Research Corp., NY.; Environmental Monitoring and Services, Inc., Washington, DC.; Environmental Protection Agency, Washington, DC. Office of Health and
Supplemental Notes See also PB-223 159. Prepared in cooperation with Environmental Monitoring and Services, Inc., Washington, DC. Sponsored by Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment.
Document Type Technical Report
Title Note Final rept.
NTIS Issue Number 199314
Contract Number
  • EPA-68-03-3112
  • EPA-68-03-3182
Evaluation of the Potential Carcinogenicity of Amitrole (61-82-5).
Evaluation of the Potential Carcinogenicity of Amitrole (61-82-5).
PB93181659

  • Carcinogens
  • Toxicity
  • Amitrole
  • Humans
  • Animals
  • Dose-response relationships
  • Carcinogenicity tests
  • CAS 61-82-5
  • Environmental Protection Agency Office of Research and Development
  • 57Y - Toxicology
  • EPA-68-03-3112
  • EPA-68-03-3182
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