National Technical Reports Library - NTRL

National Technical Reports Library


Details
Actions:
Download PDFDownload XML
Download

Inhaled Toxic Agents: An Evaluation of Dose.


PB93160877

Publication Date 1993
Personal Author Hanna, L. M.
Page Count 108
Abstract A mathematical model was developed for the absorption of gases or vapors in the respiratory tract for use in determining the dose of inhaled gases and vapors to the airways of an individual and to extrapolate doses from animals to human subjects. The physical and chemical properties of the gas or vapor determine its absorption and must be considered in extrapolation between species. The method developed depends on determining the dimensions of the airspace surrounding each turbinate and assumes the airspace is geometrically similar to an annulus or a duct. The method may be used to quantify regional variability in airway dimensions of a population. Casted models of air passages made from cadavers were also studied and found to differ significantly from those of living human subjects. The extrapolations made using these cadaver models may not accurately reveal the flow and deposition rates found in living persons. Measurements which were made from hand traced images of airway dimensions were significantly different from measurements made with an image analyzer in which the digital data containing the scanned images were downloaded to the analyzer.
Keywords
  • Air pollution effects(Humans)
  • Toxic substances
  • Inhalation
  • Dose-response relationships
  • Mathematical models
  • Animals
  • Trachea
  • Species diversity
  • Nose
  • Mouth
  • Chemical properties
  • Physical properties
  • Anatomical models
  • Respiration
  • Airway resistance
Source Agency
  • National Institute for Occupational Safety and Health
NTIS Subject Category
  • 68G - Environmental Health & Safety
  • 57U - Public Health & Industrial Medicine
  • 57A - Anatomy
Corporate Authors Johns Hopkins Univ., Baltimore, MD. School of Hygiene and Public Health.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Supplemental Notes Sponsored by National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type Technical Report
Title Note Final rept.
NTIS Issue Number 199311
Inhaled Toxic Agents: An Evaluation of Dose.
Inhaled Toxic Agents: An Evaluation of Dose.
PB93160877

  • Air pollution effects(Humans)
  • Toxic substances
  • Inhalation
  • Dose-response relationships
  • Mathematical models
  • Animals
  • Trachea
  • Species diversity
  • Nose
  • Mouth
  • Chemical properties
  • Physical properties
  • Anatomical models
  • Respiration
  • Airway resistance
  • National Institute for Occupational Safety and Health
  • 68G - Environmental Health & Safety
  • 57U - Public Health & Industrial Medicine
  • 57A - Anatomy
Loading