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Teratological Evaluation of Rat Fetuses After Prenatal Exposure to Industrial Chemicals.

PB93144327

Publication Date	1984
Page Count	222
Abstract	Rat fetuses were examined for teratological endpoints. The fetuses had been exposed to N,N-diethyl-m-toluamide (134623) (mDET), diethylene-glycol-monomethyl-ether (111773) (diEGME), or ethylene-glycol-monomethyl-ether (109864) (EGME), or were unexposed controls. No significant skeletal or visceral abnormalities were noted in rats exposed to mDET as compared to control animals. Exposure to diEGME caused several skeletal malformations and variations; the most common occurred in the ribs and included fused and/or wavy ribs and rudimentary cervical ribs. Administration of 50mg/kg EGME resulted in a significant increase in the percent of fetuses with visceral abnormalities.
Keywords	Teratogenic compounds Toxicity Glycols Rats Fetal development Congenital abnormalities Tables(Data) Musculoskeletal abnormalities Congenital heart defects Pathology Viscera Ribs(Bones) CAS 134-62-3 CAS 111-77-3 CAS 109-86-4 Methyl cellosolve Diethyltoluamide Diethylene glycol monomethyl ether
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57Y - Toxicology 57S - Physiology 68G - Environmental Health & Safety
Corporate Authors	Intox Labs., Inc., Redfield, AR.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Supplemental Notes	Sponsored by National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
NTIS Issue Number	199308
Contract Number	NIOSH-200-84-2720

Teratological Evaluation of Rat Fetuses After Prenatal Exposure to Industrial Chemicals.

Teratological Evaluation of Rat Fetuses After Prenatal Exposure to Industrial Chemicals.
PB93144327

Publication Date	1984
Page Count	222
Abstract	Rat fetuses were examined for teratological endpoints. The fetuses had been exposed to N,N-diethyl-m-toluamide (134623) (mDET), diethylene-glycol-monomethyl-ether (111773) (diEGME), or ethylene-glycol-monomethyl-ether (109864) (EGME), or were unexposed controls. No significant skeletal or visceral abnormalities were noted in rats exposed to mDET as compared to control animals. Exposure to diEGME caused several skeletal malformations and variations; the most common occurred in the ribs and included fused and/or wavy ribs and rudimentary cervical ribs. Administration of 50mg/kg EGME resulted in a significant increase in the percent of fetuses with visceral abnormalities.
Keywords	Teratogenic compounds Toxicity Glycols Rats Fetal development Congenital abnormalities Tables(Data) Musculoskeletal abnormalities Congenital heart defects Pathology Viscera Ribs(Bones) CAS 134-62-3 CAS 111-77-3 CAS 109-86-4 Methyl cellosolve Diethyltoluamide Diethylene glycol monomethyl ether
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57Y - Toxicology 57S - Physiology 68G - Environmental Health & Safety
Corporate Authors	Intox Labs., Inc., Redfield, AR.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Supplemental Notes	Sponsored by National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
NTIS Issue Number	199308
Contract Number	NIOSH-200-84-2720