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Teratological Evaluation of Rat Fetuses After Prenatal Exposure to Industrial Chemicals.


PB93144327

Publication Date 1984
Page Count 222
Abstract Rat fetuses were examined for teratological endpoints. The fetuses had been exposed to N,N-diethyl-m-toluamide (134623) (mDET), diethylene-glycol-monomethyl-ether (111773) (diEGME), or ethylene-glycol-monomethyl-ether (109864) (EGME), or were unexposed controls. No significant skeletal or visceral abnormalities were noted in rats exposed to mDET as compared to control animals. Exposure to diEGME caused several skeletal malformations and variations; the most common occurred in the ribs and included fused and/or wavy ribs and rudimentary cervical ribs. Administration of 50mg/kg EGME resulted in a significant increase in the percent of fetuses with visceral abnormalities.
Keywords
  • Teratogenic compounds
  • Toxicity
  • Glycols
  • Rats
  • Fetal development
  • Congenital abnormalities
  • Tables(Data)
  • Musculoskeletal abnormalities
  • Congenital heart defects
  • Pathology
  • Viscera
  • Ribs(Bones)
  • CAS 134-62-3
  • CAS 111-77-3
  • CAS 109-86-4
  • Methyl cellosolve
  • Diethyltoluamide
  • Diethylene glycol monomethyl ether
Source Agency
  • National Institute for Occupational Safety and Health
NTIS Subject Category
  • 57Y - Toxicology
  • 57S - Physiology
  • 68G - Environmental Health & Safety
Corporate Authors Intox Labs., Inc., Redfield, AR.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Supplemental Notes Sponsored by National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type Technical Report
NTIS Issue Number 199308
Contract Number
  • NIOSH-200-84-2720
Teratological Evaluation of Rat Fetuses After Prenatal Exposure to Industrial Chemicals.
Teratological Evaluation of Rat Fetuses After Prenatal Exposure to Industrial Chemicals.
PB93144327

  • Teratogenic compounds
  • Toxicity
  • Glycols
  • Rats
  • Fetal development
  • Congenital abnormalities
  • Tables(Data)
  • Musculoskeletal abnormalities
  • Congenital heart defects
  • Pathology
  • Viscera
  • Ribs(Bones)
  • CAS 134-62-3
  • CAS 111-77-3
  • CAS 109-86-4
  • Methyl cellosolve
  • Diethyltoluamide
  • Diethylene glycol monomethyl ether
  • National Institute for Occupational Safety and Health
  • 57Y - Toxicology
  • 57S - Physiology
  • 68G - Environmental Health & Safety
  • NIOSH-200-84-2720
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