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Occupational Risks of Pesticide Exposure for Females. Final Report.

PB93137040

Publication Date	1992
Personal Author	Swartz, W. J.
Page Count	38
Abstract	The effects of exposure to methoxychlor (72435) (MXC) on reproductive functions in nonpregnant and pregnant mice were studied. Sexually mature virgin female CD-1-mice were exposed to 1.25, 2.5, or 5.0 milligrams (mg) MXC via oral gavage for 5 consecutive days each week for either 2 or 4 weeks. A dose dependency of MXC was noted in inducing persistent vaginal estrus. Ovaries of MXC and estradiol-17beta (E-17beta) exposed mice weighed significantly less than controls. There was also an increase in the number of atretic large follicles in the E-17beta group and in those mice treated with the two highest doses of MXC, indicating a potential reduction in the immediate fertility of the mice. Increased lipid accumulation was noted in interstitial cells and theca cells of both E-17beta treated and 5.0 mg MXC treated mice. The chemical appears to closely mimic the effects on the female ovary induced by estrogen and raises concern whether such an exposure of an adult female will interfere with the normal hormonal environment and thus jeopardize future pregnancy. These alterations appear to be reversible once exposure stops. Results revealed a significant increase in the length of gestation of mice exposed to both E-17beta and 5.0 mg MXC.
Keywords	Pesticides Occupational exposure Females Estrus Mice Animal pregnancy Methoxychlor Estradiol Dose-response relationships Reproduction(Biology) Toxicity CAS 74-43-5
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57U - Public Health & Industrial Medicine 57Y - Toxicology 68E - Pesticides Pollution & Control 68G - Environmental Health & Safety
Corporate Authors	Louisiana State Univ. Medical Center, New Orleans.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Supplemental Notes	See also PB89-200943. Sponsored by National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
Title Note	Rept. for 1 Sep 88-31 May 92.
NTIS Issue Number	199308

Occupational Risks of Pesticide Exposure for Females. Final Report.

Occupational Risks of Pesticide Exposure for Females. Final Report.
PB93137040

Publication Date	1992
Personal Author	Swartz, W. J.
Page Count	38
Abstract	The effects of exposure to methoxychlor (72435) (MXC) on reproductive functions in nonpregnant and pregnant mice were studied. Sexually mature virgin female CD-1-mice were exposed to 1.25, 2.5, or 5.0 milligrams (mg) MXC via oral gavage for 5 consecutive days each week for either 2 or 4 weeks. A dose dependency of MXC was noted in inducing persistent vaginal estrus. Ovaries of MXC and estradiol-17beta (E-17beta) exposed mice weighed significantly less than controls. There was also an increase in the number of atretic large follicles in the E-17beta group and in those mice treated with the two highest doses of MXC, indicating a potential reduction in the immediate fertility of the mice. Increased lipid accumulation was noted in interstitial cells and theca cells of both E-17beta treated and 5.0 mg MXC treated mice. The chemical appears to closely mimic the effects on the female ovary induced by estrogen and raises concern whether such an exposure of an adult female will interfere with the normal hormonal environment and thus jeopardize future pregnancy. These alterations appear to be reversible once exposure stops. Results revealed a significant increase in the length of gestation of mice exposed to both E-17beta and 5.0 mg MXC.
Keywords	Pesticides Occupational exposure Females Estrus Mice Animal pregnancy Methoxychlor Estradiol Dose-response relationships Reproduction(Biology) Toxicity CAS 74-43-5
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57U - Public Health & Industrial Medicine 57Y - Toxicology 68E - Pesticides Pollution & Control 68G - Environmental Health & Safety
Corporate Authors	Louisiana State Univ. Medical Center, New Orleans.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Supplemental Notes	See also PB89-200943. Sponsored by National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
Title Note	Rept. for 1 Sep 88-31 May 92.
NTIS Issue Number	199308