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Final Report on the Developmental Toxicity of Polyoxyethylene Sorbitan Monooleate (Cas No. 9005-65-6) in Sprague-Dawley (CD (Trade Name)) Rats on Gestational Days 6 through 15.

PB93123826

Publication Date	1992
Page Count	124
Abstract	The study was designed to verify the earlier negative findings of Polysorbate 80 developmental toxicity following oral exposure as relevant to safety assessment for human dietary exposure. Furthermore, these studies sought to more completely define the circumstances under which polysorbates may be used as vehicles for delivery of compounds to pregnant animals in laboratory investigations. Timed-mated rats were administered Tween80 (50 or 5000 mg/kg)) or vehicle (deionized/distilled water) by gavage in a volume of 5 ml/kg body weight. Females were weighed periodically, food and water measurements were taken, and animals were observed for symptoms of toxicity. On gestational day 20 uterine contents were examined to determine the number implantation sites, resorptions, dead fetuses and live fetuses. In treated rats, no treatment-related signs of toxicity were observed during the in-life phase of the study. No definitive adverse effects were noted on the growth, viability or morphological development of the conceptuses.
Keywords	Teratogenic compounds Toxicity Polysorbates Rats Congenital abnormalities Fetal development Body weight Organ weight Food consumption Water consumption Fetal death Tables(Data) CAS 9005-65-6
Source Agency	National Institute of Environmental Health Sciences
NTIS Subject Category	57Y - Toxicology 57S - Physiology
Corporate Authors	Research Triangle Inst., Research Triangle Park, NC.; National Toxicology Program, Research Triangle Park, NC.
Supplemental Notes	See also PB93-123834. Sponsored by National Toxicology Program, Research Triangle Park, NC.
Document Type	Technical Report
Title Note	Rept. for 6 Aug-7 Oct 91.
NTIS Issue Number	199305
Contract Number	N01-ES-95255

Final Report on the Developmental Toxicity of Polyoxyethylene Sorbitan Monooleate (Cas No. 9005-65-6) in Sprague-Dawley (CD (Trade Name)) Rats on Gestational Days 6 through 15.

Final Report on the Developmental Toxicity of Polyoxyethylene Sorbitan Monooleate (Cas No. 9005-65-6) in Sprague-Dawley (CD (Trade Name)) Rats on Gestational Days 6 through 15.
PB93123826

Publication Date	1992
Page Count	124
Abstract	The study was designed to verify the earlier negative findings of Polysorbate 80 developmental toxicity following oral exposure as relevant to safety assessment for human dietary exposure. Furthermore, these studies sought to more completely define the circumstances under which polysorbates may be used as vehicles for delivery of compounds to pregnant animals in laboratory investigations. Timed-mated rats were administered Tween80 (50 or 5000 mg/kg)) or vehicle (deionized/distilled water) by gavage in a volume of 5 ml/kg body weight. Females were weighed periodically, food and water measurements were taken, and animals were observed for symptoms of toxicity. On gestational day 20 uterine contents were examined to determine the number implantation sites, resorptions, dead fetuses and live fetuses. In treated rats, no treatment-related signs of toxicity were observed during the in-life phase of the study. No definitive adverse effects were noted on the growth, viability or morphological development of the conceptuses.
Keywords	Teratogenic compounds Toxicity Polysorbates Rats Congenital abnormalities Fetal development Body weight Organ weight Food consumption Water consumption Fetal death Tables(Data) CAS 9005-65-6
Source Agency	National Institute of Environmental Health Sciences
NTIS Subject Category	57Y - Toxicology 57S - Physiology
Corporate Authors	Research Triangle Inst., Research Triangle Park, NC.; National Toxicology Program, Research Triangle Park, NC.
Supplemental Notes	See also PB93-123834. Sponsored by National Toxicology Program, Research Triangle Park, NC.
Document Type	Technical Report
Title Note	Rept. for 6 Aug-7 Oct 91.
NTIS Issue Number	199305
Contract Number	N01-ES-95255