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Circular Dichroism Studies of Metal Complexes of Some Chiral Drugs.

PB93119089

Publication Date	1991
Personal Author	Jamil, M.
Page Count	128
Abstract	Circular dichroism (CD) spectroscopic studies have been utilized to investigate complex forming ability of chiral antibiotics, tetracycline, cycloserine and ampicilline with transition metal ions such as Co(2+), Ni(2+), VO(2+), and Cu(2+) in aqueous solution. The ligands and metal ions (due to their symmetric nature) have no CD bands in visible region. When metal ions and ligands solutions were mixed, complexation was indicated with the development of well defined, fairly strong CD bands in the crystal field spectral region. The conditions of pH and stoichometry were determined for maximum complexation in solution.
Keywords	Complex compounds Dichroism Antibiotics Transition metals Ligands Theses Spectrum analysis Chiral symmetry Drugs Tetracyclines Optical activity Foreign technology Circular dichroism
Source Agency	Foreign Technology-Pinstech, Islamabad, Pakistan
NTIS Subject Category	99D - Basic & Synthetic Chemistry
Corporate Authors	Quaid-i-Azam Univ., Islamabad (Pakistan). Dept. of Chemistry.
Document Type	Thesis
Title Note	Master's thesis.
NTIS Issue Number	199303

Circular Dichroism Studies of Metal Complexes of Some Chiral Drugs.

Circular Dichroism Studies of Metal Complexes of Some Chiral Drugs.
PB93119089

Publication Date	1991
Personal Author	Jamil, M.
Page Count	128
Abstract	Circular dichroism (CD) spectroscopic studies have been utilized to investigate complex forming ability of chiral antibiotics, tetracycline, cycloserine and ampicilline with transition metal ions such as Co(2+), Ni(2+), VO(2+), and Cu(2+) in aqueous solution. The ligands and metal ions (due to their symmetric nature) have no CD bands in visible region. When metal ions and ligands solutions were mixed, complexation was indicated with the development of well defined, fairly strong CD bands in the crystal field spectral region. The conditions of pH and stoichometry were determined for maximum complexation in solution.
Keywords	Complex compounds Dichroism Antibiotics Transition metals Ligands Theses Spectrum analysis Chiral symmetry Drugs Tetracyclines Optical activity Foreign technology Circular dichroism
Source Agency	Foreign Technology-Pinstech, Islamabad, Pakistan
NTIS Subject Category	99D - Basic & Synthetic Chemistry
Corporate Authors	Quaid-i-Azam Univ., Islamabad (Pakistan). Dept. of Chemistry.
Document Type	Thesis
Title Note	Master's thesis.
NTIS Issue Number	199303