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Occupational Exposures and Birth Defects. Final Performance Report.

PB93118628

Publication Date	1992
Personal Author	Mitchell, A. A.; Louik, C.
Page Count	60
Abstract	The utility of the job exposure matrix (JEM) of NIOSH in occupational teratogen research was assessed. Information was taken from the Slone Epidemiology Unit Birth Defects Study (BDS). The JEM was used to assign specific workplace exposures to the mothers and fathers of the 11,000 malformed infants in the BDS data file. BDS job title/industry codes were translated into codes compatible with the JEM. Computer software was developed to produce tabulations which provided frequencies of each listed exposure in each birth defect category as well as comparisons to the remaining categories of defects. A detailed exploration of certain aspects of the data was conducted, involving the testing of a specific hypothesis. Neither the absolute attribution of exposure nor the assessment of exposure probability by the JEM provided a credible measure of exposure. The authors conclude that the NIOSH JEM cannot be usefully applied to the BDS data base to assess risks of occupational exposures in relation to birth defects.
Keywords	Occupational exposure Epidemiologic factors Teratogenic compounds Birth defects Epidemiologic measurements Graphs(Charts) Tables(Data) Mothers Fathers Statistical data interpretation Probability Kidney abnormalities
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57U - Public Health & Industrial Medicine
Corporate Authors	Boston Univ., MA. School of Medicine.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Supplemental Notes	Sponsored by National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
NTIS Issue Number	199304

Occupational Exposures and Birth Defects. Final Performance Report.

Occupational Exposures and Birth Defects. Final Performance Report.
PB93118628

Publication Date	1992
Personal Author	Mitchell, A. A.; Louik, C.
Page Count	60
Abstract	The utility of the job exposure matrix (JEM) of NIOSH in occupational teratogen research was assessed. Information was taken from the Slone Epidemiology Unit Birth Defects Study (BDS). The JEM was used to assign specific workplace exposures to the mothers and fathers of the 11,000 malformed infants in the BDS data file. BDS job title/industry codes were translated into codes compatible with the JEM. Computer software was developed to produce tabulations which provided frequencies of each listed exposure in each birth defect category as well as comparisons to the remaining categories of defects. A detailed exploration of certain aspects of the data was conducted, involving the testing of a specific hypothesis. Neither the absolute attribution of exposure nor the assessment of exposure probability by the JEM provided a credible measure of exposure. The authors conclude that the NIOSH JEM cannot be usefully applied to the BDS data base to assess risks of occupational exposures in relation to birth defects.
Keywords	Occupational exposure Epidemiologic factors Teratogenic compounds Birth defects Epidemiologic measurements Graphs(Charts) Tables(Data) Mothers Fathers Statistical data interpretation Probability Kidney abnormalities
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57U - Public Health & Industrial Medicine
Corporate Authors	Boston Univ., MA. School of Medicine.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Supplemental Notes	Sponsored by National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
NTIS Issue Number	199304