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Prophylactic Chelation Therapy: A Review of the Literature.

PB92221423

Publication Date	1976
Personal Author	Bridbord, K.
Page Count	28
Abstract	The report presented a review of the literature concerning the usefulness of prophylactic chelation therapy as a means of controlling occupational lead (7439921) intoxication. Reports concerning both the routine use of chelation therapy to avoid high blood lead concentrations and the use of chelation therapy to lower already elevated blood lead levels were reviewed. Studies included the use of calcium-disodium-ethylenediamine-tetraacetic-acetate (EDTA) and penicillamine therapies. The general consensus of opinion among those treating the occurrence in the field was that chelation or similarly acting agents have a definite place in the treatment regimen. The prophylactic use of these agents, however, has been viewed as being somewhat harmful to the health of the individual being so treated in that it can cause kidney damage, symptomatic lead poisoning, increased absorption of lead from the gastrointestinal tract, and disruption in the metabolism of trace metals other than lead. The author concludes that no support can be given to the routine prophylactic use of chelating agents to avoid high lead levels in exposed workers.
Keywords	Chelating agents Lead poisoning Preventive medicine Reviews Occupational exposure EDTA Blood chemical analysis Kidney Intestinal absorption Metabolism Penicillamine CAS 7439-92-1
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57E - Clinical Medicine 57U - Public Health & Industrial Medicine
Corporate Authors	National Inst. for Occupational Safety and Health, Rockville, MD.
Document Type	Technical Report
NTIS Issue Number	199223

Prophylactic Chelation Therapy: A Review of the Literature.

Prophylactic Chelation Therapy: A Review of the Literature.
PB92221423

Publication Date	1976
Personal Author	Bridbord, K.
Page Count	28
Abstract	The report presented a review of the literature concerning the usefulness of prophylactic chelation therapy as a means of controlling occupational lead (7439921) intoxication. Reports concerning both the routine use of chelation therapy to avoid high blood lead concentrations and the use of chelation therapy to lower already elevated blood lead levels were reviewed. Studies included the use of calcium-disodium-ethylenediamine-tetraacetic-acetate (EDTA) and penicillamine therapies. The general consensus of opinion among those treating the occurrence in the field was that chelation or similarly acting agents have a definite place in the treatment regimen. The prophylactic use of these agents, however, has been viewed as being somewhat harmful to the health of the individual being so treated in that it can cause kidney damage, symptomatic lead poisoning, increased absorption of lead from the gastrointestinal tract, and disruption in the metabolism of trace metals other than lead. The author concludes that no support can be given to the routine prophylactic use of chelating agents to avoid high lead levels in exposed workers.
Keywords	Chelating agents Lead poisoning Preventive medicine Reviews Occupational exposure EDTA Blood chemical analysis Kidney Intestinal absorption Metabolism Penicillamine CAS 7439-92-1
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57E - Clinical Medicine 57U - Public Health & Industrial Medicine
Corporate Authors	National Inst. for Occupational Safety and Health, Rockville, MD.
Document Type	Technical Report
NTIS Issue Number	199223