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The National Technical Information Service acquires, indexes, abstracts, and archives the largest collection of U.S. government-sponsored technical reports in existence. The NTRL offers online, free and open access to these authenticated government technical reports. Technical reports and documents in its repository may be available online for free either from the issuing federal agency, the U.S. Government Publishing Office’s Federal Digital System website, or through search engines.

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Monohaloacetic Acids.

PB92206077

Publication Date	1980
Page Count	104
Abstract	The monohaloacetic acids were reviewed, including information on occupational exposure, physical properties, toxicity, and structure/activity relationships. A detailed review and analysis was conducted of the biological effects of chloroacetic-acid (79118), sodium-chloroacetate (3926623), fluoroacetic-acid (144490), sodium-fluoroacetate (62748), iodoacetic-acid (64697), sodium-iodoacetate (305533), and bromoacetic-acid (79083). Topics included: human effects; epidemiologic studies; animal toxicity; diagnosis; antidotes; absorption, distribution, metabolism, and excretion; biochemistry; mutagenicity; carcinogenicity; and teratogenicity. Accurate information on the number of workers potentially exposed to these compounds was not available. Sodium-fluoroacetate has been widely used as a mammalian pest control agent. Although these compounds have different modes of action, all of them inhibit various metabolic pathways. Based on the acute toxicity to rats, fluoroacetate was the most toxic.
Keywords	Toxicity Occupational exposure Structure-activity relationships Health hazards Metabolism Pharmacokinetics Biochemistry Mutagens Carcinogens Teratogenic compounds Monohaloacetic acids CAS 79-11-8 CAS 3926-62-3 CAS 144-49-0 CAS 62-74-8 CAS 64-69-7 CAS 305-53-3 CAS 79-08-3
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57Y - Toxicology 57U - Public Health & Industrial Medicine 99F - Physical & Theoretical Chemistry
Corporate Authors	Franklin Research Center, Silver Spring, MD.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Supplemental Notes	Sponsored by National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
NTIS Issue Number	199220
Contract Number	NIOSH-210-79-0091

Monohaloacetic Acids.

Monohaloacetic Acids.
PB92206077

Publication Date	1980
Page Count	104
Abstract	The monohaloacetic acids were reviewed, including information on occupational exposure, physical properties, toxicity, and structure/activity relationships. A detailed review and analysis was conducted of the biological effects of chloroacetic-acid (79118), sodium-chloroacetate (3926623), fluoroacetic-acid (144490), sodium-fluoroacetate (62748), iodoacetic-acid (64697), sodium-iodoacetate (305533), and bromoacetic-acid (79083). Topics included: human effects; epidemiologic studies; animal toxicity; diagnosis; antidotes; absorption, distribution, metabolism, and excretion; biochemistry; mutagenicity; carcinogenicity; and teratogenicity. Accurate information on the number of workers potentially exposed to these compounds was not available. Sodium-fluoroacetate has been widely used as a mammalian pest control agent. Although these compounds have different modes of action, all of them inhibit various metabolic pathways. Based on the acute toxicity to rats, fluoroacetate was the most toxic.
Keywords	Toxicity Occupational exposure Structure-activity relationships Health hazards Metabolism Pharmacokinetics Biochemistry Mutagens Carcinogens Teratogenic compounds Monohaloacetic acids CAS 79-11-8 CAS 3926-62-3 CAS 144-49-0 CAS 62-74-8 CAS 64-69-7 CAS 305-53-3 CAS 79-08-3
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57Y - Toxicology 57U - Public Health & Industrial Medicine 99F - Physical & Theoretical Chemistry
Corporate Authors	Franklin Research Center, Silver Spring, MD.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Supplemental Notes	Sponsored by National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
NTIS Issue Number	199220
Contract Number	NIOSH-210-79-0091