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Monohaloacetic Acids.


PB92206077

Publication Date 1980
Page Count 104
Abstract The monohaloacetic acids were reviewed, including information on occupational exposure, physical properties, toxicity, and structure/activity relationships. A detailed review and analysis was conducted of the biological effects of chloroacetic-acid (79118), sodium-chloroacetate (3926623), fluoroacetic-acid (144490), sodium-fluoroacetate (62748), iodoacetic-acid (64697), sodium-iodoacetate (305533), and bromoacetic-acid (79083). Topics included: human effects; epidemiologic studies; animal toxicity; diagnosis; antidotes; absorption, distribution, metabolism, and excretion; biochemistry; mutagenicity; carcinogenicity; and teratogenicity. Accurate information on the number of workers potentially exposed to these compounds was not available. Sodium-fluoroacetate has been widely used as a mammalian pest control agent. Although these compounds have different modes of action, all of them inhibit various metabolic pathways. Based on the acute toxicity to rats, fluoroacetate was the most toxic.
Keywords
  • Toxicity
  • Occupational exposure
  • Structure-activity relationships
  • Health hazards
  • Metabolism
  • Pharmacokinetics
  • Biochemistry
  • Mutagens
  • Carcinogens
  • Teratogenic compounds
  • Monohaloacetic acids
  • CAS 79-11-8
  • CAS 3926-62-3
  • CAS 144-49-0
  • CAS 62-74-8
  • CAS 64-69-7
  • CAS 305-53-3
  • CAS 79-08-3
Source Agency
  • National Institute for Occupational Safety and Health
NTIS Subject Category
  • 57Y - Toxicology
  • 57U - Public Health & Industrial Medicine
  • 99F - Physical & Theoretical Chemistry
Corporate Authors Franklin Research Center, Silver Spring, MD.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Supplemental Notes Sponsored by National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type Technical Report
NTIS Issue Number 199220
Contract Number
  • NIOSH-210-79-0091
Monohaloacetic Acids.
Monohaloacetic Acids.
PB92206077

  • Toxicity
  • Occupational exposure
  • Structure-activity relationships
  • Health hazards
  • Metabolism
  • Pharmacokinetics
  • Biochemistry
  • Mutagens
  • Carcinogens
  • Teratogenic compounds
  • Monohaloacetic acids
  • CAS 79-11-8
  • CAS 3926-62-3
  • CAS 144-49-0
  • CAS 62-74-8
  • CAS 64-69-7
  • CAS 305-53-3
  • CAS 79-08-3
  • National Institute for Occupational Safety and Health
  • 57Y - Toxicology
  • 57U - Public Health & Industrial Medicine
  • 99F - Physical & Theoretical Chemistry
  • NIOSH-210-79-0091
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