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Evaluation of the Peripheral Nervous System Among Workers Employed in the Production of Chemicals Contaminated with 2,3,7.8-Tetra-chlorodibenzo-P-Dioxin.

PB92206069

Publication Date	1990
Personal Author	Sweeney, M. H.; Fingerhut, M. A.; Connally, L. B.; Hornung, R.
Page Count	332
Abstract	The long term effects on the peripheral nervous system in workers with past exposure to production products contaminated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (1746016) (TCDD) were evaluated. The severity of the current neurologic status was compared to the levels of TCDD measured in the serum of study subjects. Workers who were employed at two chemical factories at which chemicals contaminated with TCDD were manufactured, and a group of unexposed referents were assessed in a cross sectional medical study in 1987 through 1988. Questionnaires were used to collect follow-up data. There were 281 workers and 260 referents who were interviewed and medically examined. Peripheral neuropathy was found in about 18% of workers and 19% of referents. Serum TCDD levels ranged from 2 to 3390 parts per trillion (ppt) for 272 workers and from 2 to 20ppt for 86 referents tested. No dose-response relationship was observed between TCDD levels present at the time of the examination and the occurrence of peripheral neuropathy in the previously exposed population. The authors conclude that exposure to TCDD caused no excess chronic peripheral neuropathy in a group of exposed workers compared to unexposed referents.
Keywords	Occupational exposure Peripheral nerves Toxicity Tetrachlorodibenzodioxin Neoplasms Chemical industry Electrophysiology Tables(Data) Dose-response relationships Humans Cross-sectional studies Animals Tissue distribution Blood Regression analysis Reproduction(Biology) CAS 1746-01-6
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57U - Public Health & Industrial Medicine 57Y - Toxicology
Corporate Authors	National Inst. for Occupational Safety and Health, Cincinnati, OH. Div. of Surveillance, Hazard Evaluations and Field Studies.
Document Type	Technical Report
Title Note	Final rept.
NTIS Issue Number	199222

Evaluation of the Peripheral Nervous System Among Workers Employed in the Production of Chemicals Contaminated with 2,3,7.8-Tetra-chlorodibenzo-P-Dioxin.

Evaluation of the Peripheral Nervous System Among Workers Employed in the Production of Chemicals Contaminated with 2,3,7.8-Tetra-chlorodibenzo-P-Dioxin.
PB92206069

Publication Date	1990
Personal Author	Sweeney, M. H.; Fingerhut, M. A.; Connally, L. B.; Hornung, R.
Page Count	332
Abstract	The long term effects on the peripheral nervous system in workers with past exposure to production products contaminated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (1746016) (TCDD) were evaluated. The severity of the current neurologic status was compared to the levels of TCDD measured in the serum of study subjects. Workers who were employed at two chemical factories at which chemicals contaminated with TCDD were manufactured, and a group of unexposed referents were assessed in a cross sectional medical study in 1987 through 1988. Questionnaires were used to collect follow-up data. There were 281 workers and 260 referents who were interviewed and medically examined. Peripheral neuropathy was found in about 18% of workers and 19% of referents. Serum TCDD levels ranged from 2 to 3390 parts per trillion (ppt) for 272 workers and from 2 to 20ppt for 86 referents tested. No dose-response relationship was observed between TCDD levels present at the time of the examination and the occurrence of peripheral neuropathy in the previously exposed population. The authors conclude that exposure to TCDD caused no excess chronic peripheral neuropathy in a group of exposed workers compared to unexposed referents.
Keywords	Occupational exposure Peripheral nerves Toxicity Tetrachlorodibenzodioxin Neoplasms Chemical industry Electrophysiology Tables(Data) Dose-response relationships Humans Cross-sectional studies Animals Tissue distribution Blood Regression analysis Reproduction(Biology) CAS 1746-01-6
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57U - Public Health & Industrial Medicine 57Y - Toxicology
Corporate Authors	National Inst. for Occupational Safety and Health, Cincinnati, OH. Div. of Surveillance, Hazard Evaluations and Field Studies.
Document Type	Technical Report
Title Note	Final rept.
NTIS Issue Number	199222