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Prenatal and Postnatal Exposure to Lead in Relation to Infant Development: A Review.

PB92205921

Publication Date	1992
Personal Author	Hatch, M. C.
Page Count	26
Abstract	The report reviewed and evaluated the evidence concerning lead (7439921) exposure and infant development from prospective studies in Boston, Cincinnati and Cleveland in the United States as well as in Port Pirie, Australia; Kosovo, Yugoslavia; and Christchurch, New Zealand. The Boston and Cincinnati studies both found deficits in visual/motor skills in relation to prenatal and neonatal lead burdens. In the Port Pirie cohort the primary source of lead exposure was a smelter located upwind of the city. Blood lead levels of 8.3 micrograms/deciliter (microg/dl) prenatally and 2.1 microg/dl in the postnatal period were determined in the mostly middle class population. Beginning at age 2 the blood lead levels were related to measurable deficits in the developmental assessment at age 4, primarily in nonverbal skills. The Yugoslavian population was also residing near a lead smelter and demonstrated a mean of 17.1 microg/dl prenatally and 35.5 microg/dl in the postnatal period. Deficits were found in development at age 2 for prenatal as well as in postnatal blood lead. Each of the studied populations revealed that lead exposures sufficient to produce body burdens on the order of 10 microg/dl in blood, either prenatally or postnatally, caused small reductions in infant and child cognitive ability as estimated by IQ tests.
Keywords	Lead Public health Maternal-fetal exchange Exposure Infants Smelters Cognition disorders Cohort studies Child development disorders Body burden Occupational exposure United States Foreign countries CAS 7439-92-1
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57U - Public Health & Industrial Medicine 57S - Physiology
Corporate Authors	Columbia Univ., New York. Div. of Epidemiology.; National Inst. for Occupational Safety and Health, Cincinnati, OH. Div.
Supplemental Notes	Sponsored by National Inst. for Occupational Safety and Health, Cincinnati, OH. Div. of Standards Development and Technology Transfer.
Document Type	Technical Report
NTIS Issue Number	199220

Prenatal and Postnatal Exposure to Lead in Relation to Infant Development: A Review.

Prenatal and Postnatal Exposure to Lead in Relation to Infant Development: A Review.
PB92205921

Publication Date	1992
Personal Author	Hatch, M. C.
Page Count	26
Abstract	The report reviewed and evaluated the evidence concerning lead (7439921) exposure and infant development from prospective studies in Boston, Cincinnati and Cleveland in the United States as well as in Port Pirie, Australia; Kosovo, Yugoslavia; and Christchurch, New Zealand. The Boston and Cincinnati studies both found deficits in visual/motor skills in relation to prenatal and neonatal lead burdens. In the Port Pirie cohort the primary source of lead exposure was a smelter located upwind of the city. Blood lead levels of 8.3 micrograms/deciliter (microg/dl) prenatally and 2.1 microg/dl in the postnatal period were determined in the mostly middle class population. Beginning at age 2 the blood lead levels were related to measurable deficits in the developmental assessment at age 4, primarily in nonverbal skills. The Yugoslavian population was also residing near a lead smelter and demonstrated a mean of 17.1 microg/dl prenatally and 35.5 microg/dl in the postnatal period. Deficits were found in development at age 2 for prenatal as well as in postnatal blood lead. Each of the studied populations revealed that lead exposures sufficient to produce body burdens on the order of 10 microg/dl in blood, either prenatally or postnatally, caused small reductions in infant and child cognitive ability as estimated by IQ tests.
Keywords	Lead Public health Maternal-fetal exchange Exposure Infants Smelters Cognition disorders Cohort studies Child development disorders Body burden Occupational exposure United States Foreign countries CAS 7439-92-1
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57U - Public Health & Industrial Medicine 57S - Physiology
Corporate Authors	Columbia Univ., New York. Div. of Epidemiology.; National Inst. for Occupational Safety and Health, Cincinnati, OH. Div.
Supplemental Notes	Sponsored by National Inst. for Occupational Safety and Health, Cincinnati, OH. Div. of Standards Development and Technology Transfer.
Document Type	Technical Report
NTIS Issue Number	199220