National Technical Reports Library

The National Technical Information Service acquires, indexes, abstracts, and archives the largest collection of U.S. government-sponsored technical reports in existence. The NTRL offers online, free and open access to these authenticated government technical reports. Technical reports and documents in its repository may be available online for free either from the issuing federal agency, the U.S. Government Publishing Office’s Federal Digital System website, or through search engines.

Details

Final Report on the Developmental Toxicity of Dipropylene Glycol (CAS No. 25265-71-8) in Sprague-Dawley (CD (Trade Name)) Rats.

PB92196179

Publication Date	1992
Personal Author	Bates, H. K.; Price, C. J.; Marr, M. C.; Myers, C. B.; Heindel, J. J.
Page Count	166
Abstract	Dipropylene glycol (DPG) is a high production glycol used in the manufacture of nitrocellulose solvent, lacquers, paints, printing inks, and shellac varnishes. In general, the toxicity of the glycols decreases as the molecular weight of the molecule increases. Therefore, it could be predicted that DPG would be less toxic than low molecular weight glycols such as ethylene glycol. Since, there is a lack of data with which to confirm this hypothesis the study was conducted to assess the potential for DPG to cause developmental toxicity and to compare its toxicity to other glycols. DPG (CAS No. 25265-71-8) was administered by gavage to timed-pregnant CD rats (20-25/group) on gestational days (GD) 6-15 at dose levels of 0, 800, 2000, or 5000 mg/kg body weight/day. Animals were observed daily for clinical signs of toxicity. Food and water weights and body weights were reported on GD 0, 3, 6, 9, 12, 15, 18, and 20. All animals were killed on GD 20 and examined for maternal body and organ weights, implant status, fetal weight, sex, and morphological development. Results showed no maternal or developmental toxicity at 800 mg/kg/day of DPG. Maternal toxicity and lethality were observed at 2000 and 5000 mg/kg/day, but developmental toxicity was not observed even at these maternally lethal exposures.
Keywords	Toxicity Teratogenic compounds Congenital abnormalities Rats Tables(Data) Body weight Food consumption Organ weight Water consumption Metabolism Dose-response relationships Dipropylene glycol CAS 25265-71-8
Source Agency	National Institute of Environmental Health Sciences
NTIS Subject Category	57Y - Toxicology 57S - Physiology
Corporate Authors	Research Triangle Inst., Research Triangle Park, NC.; National Toxicology Program, Research Triangle Park, NC.
Supplemental Notes	See also Laboratory Supplement, PB92-196187. Sponsored by National Toxicology Program, Research Triangle Park, NC.
Document Type	Technical Report
Title Note	Technical rept. 19 Jun-12 Sep 90.
NTIS Issue Number	199218
Contract Number	N01-ES-95255

Final Report on the Developmental Toxicity of Dipropylene Glycol (CAS No. 25265-71-8) in Sprague-Dawley (CD (Trade Name)) Rats.

Final Report on the Developmental Toxicity of Dipropylene Glycol (CAS No. 25265-71-8) in Sprague-Dawley (CD (Trade Name)) Rats.
PB92196179

Publication Date	1992
Personal Author	Bates, H. K.; Price, C. J.; Marr, M. C.; Myers, C. B.; Heindel, J. J.
Page Count	166
Abstract	Dipropylene glycol (DPG) is a high production glycol used in the manufacture of nitrocellulose solvent, lacquers, paints, printing inks, and shellac varnishes. In general, the toxicity of the glycols decreases as the molecular weight of the molecule increases. Therefore, it could be predicted that DPG would be less toxic than low molecular weight glycols such as ethylene glycol. Since, there is a lack of data with which to confirm this hypothesis the study was conducted to assess the potential for DPG to cause developmental toxicity and to compare its toxicity to other glycols. DPG (CAS No. 25265-71-8) was administered by gavage to timed-pregnant CD rats (20-25/group) on gestational days (GD) 6-15 at dose levels of 0, 800, 2000, or 5000 mg/kg body weight/day. Animals were observed daily for clinical signs of toxicity. Food and water weights and body weights were reported on GD 0, 3, 6, 9, 12, 15, 18, and 20. All animals were killed on GD 20 and examined for maternal body and organ weights, implant status, fetal weight, sex, and morphological development. Results showed no maternal or developmental toxicity at 800 mg/kg/day of DPG. Maternal toxicity and lethality were observed at 2000 and 5000 mg/kg/day, but developmental toxicity was not observed even at these maternally lethal exposures.
Keywords	Toxicity Teratogenic compounds Congenital abnormalities Rats Tables(Data) Body weight Food consumption Organ weight Water consumption Metabolism Dose-response relationships Dipropylene glycol CAS 25265-71-8
Source Agency	National Institute of Environmental Health Sciences
NTIS Subject Category	57Y - Toxicology 57S - Physiology
Corporate Authors	Research Triangle Inst., Research Triangle Park, NC.; National Toxicology Program, Research Triangle Park, NC.
Supplemental Notes	See also Laboratory Supplement, PB92-196187. Sponsored by National Toxicology Program, Research Triangle Park, NC.
Document Type	Technical Report
Title Note	Technical rept. 19 Jun-12 Sep 90.
NTIS Issue Number	199218
Contract Number	N01-ES-95255