National Technical Reports Library

The National Technical Information Service acquires, indexes, abstracts, and archives the largest collection of U.S. government-sponsored technical reports in existence. The NTRL offers online, free and open access to these authenticated government technical reports. Technical reports and documents in its repository may be available online for free either from the issuing federal agency, the U.S. Government Publishing Office’s Federal Digital System website, or through search engines.

Details

Dose-Response Analysis and Quantitative Assessment of Lung Cancer Risk and Occupational Cadmium Exposure.

PB92184282

Publication Date	1990
Personal Author	Stayner, L.; Smith, R.; Thun, M.; Schnorr, T.; Lemen, R.
Page Count	38
Abstract	A quantitative assessment was performed of the risk of lung cancer from exposure to cadmium (7440439) in a population of workers at a facility that processed cadmium metals and compounds. The population consisted of all workers who worked in a production area for at least 6 months from 1940 through 1969; the vital status of the workers was updated through 1984. A total of 606 white male workers, contributing 16,898 person years and 162 deaths were analyzed. A statistically significant dose response was evident in nearly all of the Poisson regression models evaluated. A nearly significant excess in mortality from lung cancer was noted for the entire cohort. Mortality from lung cancer was significantly elevated among non Hispanic workers, workers in the highest cadmium exposure group, and among workers with 20 or more years since first exposure. Based on these analyses, the lifetime excess lung cancer risk at the current OSHA standard for cadmium fumes of 100 micrograms per cubic meter was estimated to be approximately 50 to 111 lung cancer deaths per 1000 workers exposed to cadmium for 45 years. The authors conclude that efforts should be made to further reduce the risk by lowering occupational exposures to cadmium to the lowest level feasible.
Keywords	Cadmium Toxicity Pulmonary neoplasms Occupational exposure Risk Dose-response relationships Cohort studies Mortality rates Statistical models Regression analysis
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57Y - Toxicology 57U - Public Health & Industrial Medicine
Corporate Authors	National Inst. for Occupational Safety and Health, Cincinnati, OH. Div. of Standards Development and Technology Transfer.
Document Type	Technical Report
NTIS Issue Number	199215

Dose-Response Analysis and Quantitative Assessment of Lung Cancer Risk and Occupational Cadmium Exposure.

Dose-Response Analysis and Quantitative Assessment of Lung Cancer Risk and Occupational Cadmium Exposure.
PB92184282

Publication Date	1990
Personal Author	Stayner, L.; Smith, R.; Thun, M.; Schnorr, T.; Lemen, R.
Page Count	38
Abstract	A quantitative assessment was performed of the risk of lung cancer from exposure to cadmium (7440439) in a population of workers at a facility that processed cadmium metals and compounds. The population consisted of all workers who worked in a production area for at least 6 months from 1940 through 1969; the vital status of the workers was updated through 1984. A total of 606 white male workers, contributing 16,898 person years and 162 deaths were analyzed. A statistically significant dose response was evident in nearly all of the Poisson regression models evaluated. A nearly significant excess in mortality from lung cancer was noted for the entire cohort. Mortality from lung cancer was significantly elevated among non Hispanic workers, workers in the highest cadmium exposure group, and among workers with 20 or more years since first exposure. Based on these analyses, the lifetime excess lung cancer risk at the current OSHA standard for cadmium fumes of 100 micrograms per cubic meter was estimated to be approximately 50 to 111 lung cancer deaths per 1000 workers exposed to cadmium for 45 years. The authors conclude that efforts should be made to further reduce the risk by lowering occupational exposures to cadmium to the lowest level feasible.
Keywords	Cadmium Toxicity Pulmonary neoplasms Occupational exposure Risk Dose-response relationships Cohort studies Mortality rates Statistical models Regression analysis
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57Y - Toxicology 57U - Public Health & Industrial Medicine
Corporate Authors	National Inst. for Occupational Safety and Health, Cincinnati, OH. Div. of Standards Development and Technology Transfer.
Document Type	Technical Report
NTIS Issue Number	199215