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Final Report on the Reproductive Toxicity of Ortho-Cresol (OCRE) in CD-1 Swiss Mice II. Volume 1.

PB92176890

Publication Date	1992
Personal Author	George, J. D.; Fail, P. A.; Izard, M. K.; Grizzle, T. B.; Heindel, J. J.
Page Count	242
Abstract	Ortho-cresol (OCRE), one of three isomers of cresol which are used in the wood preservative creosote and as disinfectants, solvents, and cleaners, was evaluated for reproductive toxicity in CD-1 (Swiss) mice using the Reproductive Assessment by Continuous Breeding Protocol (RACB). Exposure to OCRE at levels ranging from a mean of 66 mg/kg/day in the low-dose group (0.05% in feed) to a mean of 660 mg/kg/day in the high-dose group (0.5% in feed) for 14 weeks of cohabitation did not significantly affect measures of reproductive competence, including initial fertility, mean number of litters per pair, live litter size, the proportion of pups born alive, or adjusted live pup weight. In summary, exposure to OCRE in feed at dose levels as high as 0.5% had no significant adverse effect on reproductive competence in F0 or F1 mice. However, the maximum tolerated dose (MTD) was not reached, because no evidence of generalized toxicity was noted for the F0 generation at 0.5% OCRE, and only minimal evidence of generalized toxicity was noted for F1 females at 0.5% OCRE. Although the MTD was not reached for the F0 generation, data from Task 1 suggested that the animals could not have tolerated higher doses for the length of exposures in Tasks 2 and 3. The 0.2% dose level was the no adverse effects level (NOAEL) for both reproductive and general toxicity in both generations.
Keywords	Cresols Reproduction(Biology) Fertility Body weight Organ weight Mice Food consumption Water consumption Dose-response relationships Lactation Tables(Data) CAS 95-48-7
Source Agency	National Institute of Environmental Health Sciences
NTIS Subject Category	57Y - Toxicology 57S - Physiology
Corporate Authors	Research Triangle Inst., Research Triangle Park, NC. Center for Life Sciences and Toxicology.; National Toxicology Program, Research Triangle Park, NC.
Supplemental Notes	See also Volume 2, PB92-176908. See also PB88-197496. Sponsored by National Toxicology Program, Research Triangle Park, NC.
Document Type	Technical Report
NTIS Issue Number	199214
Contract Number	N01-ES-65141

Final Report on the Reproductive Toxicity of Ortho-Cresol (OCRE) in CD-1 Swiss Mice II. Volume 1.

Final Report on the Reproductive Toxicity of Ortho-Cresol (OCRE) in CD-1 Swiss Mice II. Volume 1.
PB92176890

Publication Date	1992
Personal Author	George, J. D.; Fail, P. A.; Izard, M. K.; Grizzle, T. B.; Heindel, J. J.
Page Count	242
Abstract	Ortho-cresol (OCRE), one of three isomers of cresol which are used in the wood preservative creosote and as disinfectants, solvents, and cleaners, was evaluated for reproductive toxicity in CD-1 (Swiss) mice using the Reproductive Assessment by Continuous Breeding Protocol (RACB). Exposure to OCRE at levels ranging from a mean of 66 mg/kg/day in the low-dose group (0.05% in feed) to a mean of 660 mg/kg/day in the high-dose group (0.5% in feed) for 14 weeks of cohabitation did not significantly affect measures of reproductive competence, including initial fertility, mean number of litters per pair, live litter size, the proportion of pups born alive, or adjusted live pup weight. In summary, exposure to OCRE in feed at dose levels as high as 0.5% had no significant adverse effect on reproductive competence in F0 or F1 mice. However, the maximum tolerated dose (MTD) was not reached, because no evidence of generalized toxicity was noted for the F0 generation at 0.5% OCRE, and only minimal evidence of generalized toxicity was noted for F1 females at 0.5% OCRE. Although the MTD was not reached for the F0 generation, data from Task 1 suggested that the animals could not have tolerated higher doses for the length of exposures in Tasks 2 and 3. The 0.2% dose level was the no adverse effects level (NOAEL) for both reproductive and general toxicity in both generations.
Keywords	Cresols Reproduction(Biology) Fertility Body weight Organ weight Mice Food consumption Water consumption Dose-response relationships Lactation Tables(Data) CAS 95-48-7
Source Agency	National Institute of Environmental Health Sciences
NTIS Subject Category	57Y - Toxicology 57S - Physiology
Corporate Authors	Research Triangle Inst., Research Triangle Park, NC. Center for Life Sciences and Toxicology.; National Toxicology Program, Research Triangle Park, NC.
Supplemental Notes	See also Volume 2, PB92-176908. See also PB88-197496. Sponsored by National Toxicology Program, Research Triangle Park, NC.
Document Type	Technical Report
NTIS Issue Number	199214
Contract Number	N01-ES-65141