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Criteria for a Recommended Standard. Occupational Exposure to Ethylene Glycol Monomethyl Ether, Ethylene Glycol Monomethyl Ether and Their Acetates.

PB92167147

Publication Date	1991
Page Count	314
Abstract	Occupational health risks associated with exposure to ethylene-glycol-monomethyl-ether (109864) (EGME), ethylene-glycol-monomethyl-ether (110805) (EGEE), ethylene-glycol-monomethyl-ether-acetate (110496) (EGMEA) and ethylene-glycol-monoethyl-ether-acetate (110496) (EGEEA) were examined. The glycol ethers were shown to adversely affect the blood, central nervous and hematopoietic systems, liver and kidneys. Dose related malformations, growth retardation and embryonic death have been demonstrated in the offspring of pregnant animals exposed to airborne concentrations of these chemicals. Testicular atrophy and infertility occurred in male animals exposed to airborne EGME or EGEE at or below their current PELs. NIOSH recommends that exposure to EGME and EGMEA in the workplace be limited to 0.1 parts per million (ppm) of air as a time weighted average for up to 10 hours/day in a 40 hour work week. NIOSH also recommended that exposure to EGEE and EGEEA be limited to 0.5ppm as a 10 hour time weight average exposure limit. State of the art engineering controls and work practices are to be used to bring about these reductions. EGME, EGEE, and their acetates are readily absorbed through the skin, thus making dermal contact unsafe.
Keywords	Occupational exposure Acetates Toxicology Bone marrow Central nervous system Dose-response relationships Kidney Embryo Testis Tables(Data) Liver Occupational air pollutants Protective clothing Humans Laboratory animals Pregnancy Ethylene glycol monomethyl ether Ethylene glycol monoethyl ether CAS 109-86-4 CAS 110-49-6
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57U - Public Health & Industrial Medicine 57Y - Toxicology
Corporate Authors	National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
NTIS Issue Number	199213

Criteria for a Recommended Standard. Occupational Exposure to Ethylene Glycol Monomethyl Ether, Ethylene Glycol Monomethyl Ether and Their Acetates.

Criteria for a Recommended Standard. Occupational Exposure to Ethylene Glycol Monomethyl Ether, Ethylene Glycol Monomethyl Ether and Their Acetates.
PB92167147

Publication Date	1991
Page Count	314
Abstract	Occupational health risks associated with exposure to ethylene-glycol-monomethyl-ether (109864) (EGME), ethylene-glycol-monomethyl-ether (110805) (EGEE), ethylene-glycol-monomethyl-ether-acetate (110496) (EGMEA) and ethylene-glycol-monoethyl-ether-acetate (110496) (EGEEA) were examined. The glycol ethers were shown to adversely affect the blood, central nervous and hematopoietic systems, liver and kidneys. Dose related malformations, growth retardation and embryonic death have been demonstrated in the offspring of pregnant animals exposed to airborne concentrations of these chemicals. Testicular atrophy and infertility occurred in male animals exposed to airborne EGME or EGEE at or below their current PELs. NIOSH recommends that exposure to EGME and EGMEA in the workplace be limited to 0.1 parts per million (ppm) of air as a time weighted average for up to 10 hours/day in a 40 hour work week. NIOSH also recommended that exposure to EGEE and EGEEA be limited to 0.5ppm as a 10 hour time weight average exposure limit. State of the art engineering controls and work practices are to be used to bring about these reductions. EGME, EGEE, and their acetates are readily absorbed through the skin, thus making dermal contact unsafe.
Keywords	Occupational exposure Acetates Toxicology Bone marrow Central nervous system Dose-response relationships Kidney Embryo Testis Tables(Data) Liver Occupational air pollutants Protective clothing Humans Laboratory animals Pregnancy Ethylene glycol monomethyl ether Ethylene glycol monoethyl ether CAS 109-86-4 CAS 110-49-6
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57U - Public Health & Industrial Medicine 57Y - Toxicology
Corporate Authors	National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
NTIS Issue Number	199213