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Colchicine Inhibits Elevations in Both Alveolar-Capillary Membrane Permeability and Lavage Surfactant After Exposure of the Rat to Phosgene.

PB92136332

Publication Date	1991
Personal Author	Ghio, A. J.; Hatch, G. E.
Page Count	30
Abstract	Changes were measured in the permeability of the alveolar capillary membrane and lavage surfactant concentrations following phosgene (75445) exposure and the influence of colchicine on both. Male Sprague-Dawley rats were treated with either colchicine at 1.0mg/kg or saline intraperitoneally 30 minutes prior to exposure to phosgene at 0.5 parts per million for 60 minutes and air. Lavage surfactant was quantified as the total phosphorus immediately and 1 day after exposure. The two sources of protein showed very different responses to phosgene. Permeability was elevated immediately but returned to normal values one day after inhalation. Values of total phospholipid in the lavage fluid showed no immediate differences between phosgene and air exposed rats. However, significant increases were observed 1 day after phosgene inhalation. Colchicine inhibited both the immediate rise in the permeability index and the elevation of total phospholipid 1 day after phosgene exposure.
Keywords	Toxicology Colchicine Phosgene Pulmonary alveoli Rats Cell membrane permeability Bronchoalveolar lavage fluid Phosphorus Neutrophils Proteins Pulmonary surfactants Respiratory distress syndrome CAS 75-44-5
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57Y - Toxicology
Corporate Authors	Duke Univ., Durham, NC. Dept. of Medicine. Health Effects Research Lab., Research Triangle Park, NC. Inhalation Toxicology Div.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Supplemental Notes	Prepared in cooperation with Health Effects Research Lab., Research Triangle Park, NC. Inhalation Toxicology Div. Sponsored by National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
NTIS Issue Number	199209

Colchicine Inhibits Elevations in Both Alveolar-Capillary Membrane Permeability and Lavage Surfactant After Exposure of the Rat to Phosgene.

Colchicine Inhibits Elevations in Both Alveolar-Capillary Membrane Permeability and Lavage Surfactant After Exposure of the Rat to Phosgene.
PB92136332

Publication Date	1991
Personal Author	Ghio, A. J.; Hatch, G. E.
Page Count	30
Abstract	Changes were measured in the permeability of the alveolar capillary membrane and lavage surfactant concentrations following phosgene (75445) exposure and the influence of colchicine on both. Male Sprague-Dawley rats were treated with either colchicine at 1.0mg/kg or saline intraperitoneally 30 minutes prior to exposure to phosgene at 0.5 parts per million for 60 minutes and air. Lavage surfactant was quantified as the total phosphorus immediately and 1 day after exposure. The two sources of protein showed very different responses to phosgene. Permeability was elevated immediately but returned to normal values one day after inhalation. Values of total phospholipid in the lavage fluid showed no immediate differences between phosgene and air exposed rats. However, significant increases were observed 1 day after phosgene inhalation. Colchicine inhibited both the immediate rise in the permeability index and the elevation of total phospholipid 1 day after phosgene exposure.
Keywords	Toxicology Colchicine Phosgene Pulmonary alveoli Rats Cell membrane permeability Bronchoalveolar lavage fluid Phosphorus Neutrophils Proteins Pulmonary surfactants Respiratory distress syndrome CAS 75-44-5
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57Y - Toxicology
Corporate Authors	Duke Univ., Durham, NC. Dept. of Medicine. Health Effects Research Lab., Research Triangle Park, NC. Inhalation Toxicology Div.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Supplemental Notes	Prepared in cooperation with Health Effects Research Lab., Research Triangle Park, NC. Inhalation Toxicology Div. Sponsored by National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
NTIS Issue Number	199209