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Final Report on the Reproductive Toxicity of Tris(2-Chloroethyl)phosphate Reproduction and Fertility Assessment in Swiss CD-1 Mice When Administered via Gavage.


PB92129170

Publication Date 1991
Personal Author Gulati, D. K.; Barnes, L. H.; Chapin, R. E.; Heindel, J.
Page Count 270
Abstract Tris(2-chloroethyl)phosphate (TCEP) is one of the class of tris organophosphates. It is used as a flame-retardant for plastics and synthetic fibers. TCEP was tested for its effects on fertility and reproduction in Swiss CD-1 mice according to the Continuous Breeding Protocol. It was administered via gavage. Based on results of previous data and a dose-finding study, 175, 350, and 700 mg/kg bw were chosen to investigate effects on fertility and reproduction.
Keywords
  • Toxicity
  • Reproduction(Biology)
  • Fire resistant coatings
  • Body weight
  • Mice
  • Dose-response relationships
  • Litter size
  • Tables(Data)
  • Fertility
  • Organ weight
  • Kidney
  • Water consumption
  • Tris(2-chloroethyl)phosphate)
  • CAS 115-96-8
Source Agency
  • National Institute of Environmental Health Sciences
NTIS Subject Category
  • 57Y - Toxicology
  • 57S - Physiology
Corporate Authors Environmental Health Research and Testing, Inc., Lexington, KY.; National Toxicology Program, Research Triangle Park, NC.
Supplemental Notes See also PB91-171728. Sponsored by National Toxicology Program, Research Triangle Park, NC.
Document Type Technical Report
NTIS Issue Number 199207
Contract Number
  • NTP-NO1-ES-65142
Final Report on the Reproductive Toxicity of Tris(2-Chloroethyl)phosphate Reproduction and Fertility Assessment in Swiss CD-1 Mice When Administered via Gavage.
Final Report on the Reproductive Toxicity of Tris(2-Chloroethyl)phosphate Reproduction and Fertility Assessment in Swiss CD-1 Mice When Administered via Gavage.
PB92129170

  • Toxicity
  • Reproduction(Biology)
  • Fire resistant coatings
  • Body weight
  • Mice
  • Dose-response relationships
  • Litter size
  • Tables(Data)
  • Fertility
  • Organ weight
  • Kidney
  • Water consumption
  • Tris(2-chloroethyl)phosphate)
  • CAS 115-96-8
  • National Institute of Environmental Health Sciences
  • 57Y - Toxicology
  • 57S - Physiology
  • NTP-NO1-ES-65142
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