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Details

Immune Responsiveness in Chlorine Exposed Rats.

PB92124478

Publication Date	1991
Personal Author	O'Neil, C. E.
Page Count	26
Abstract	A mouse model was developed to test the hypothesis that acute exposure to high levels of chlorine (7782505) gas can increase sensitivity to inhaled antigen. The initial survey was designed to assess whether there was an increse in sensitivity to antigen and whether the effect was transient or of extended duration. BALB/c-mice were exposed to 200 or 150 parts per million (ppm) chlorine for 1 hour. The animals were then exposed to 1% aerosolized bovine serum albumin (BSA) immediately or 1, 3, 7, and 30 days after exposure. Exposures were for 30 minutes a day for 5 consecutive days. The findings indicated that in mice, acute exposure to 200ppm followed immediately by exposure to BSA resulted in increased levels of antigen specific immunoglobulin-G when compared to control values. Mice exposed acutely to lower levels of chlorine or to antigen at more distant time points following the irritant exposure did not demonstrate any increased antibody levels.
Keywords	Chlorine Immunology Mice Bovine serum albumin IgG Antigens Antibodies Exposure Lung CAS 7782-50-5
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57Y - Toxicology 57J - Immunology
Corporate Authors	Tulane Univ., New Orleans, LA. School of Medicine.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Supplemental Notes	Sponsored by National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
Title Note	Progress rept. (Final).
NTIS Issue Number	199206

Immune Responsiveness in Chlorine Exposed Rats.

Immune Responsiveness in Chlorine Exposed Rats.
PB92124478

Publication Date	1991
Personal Author	O'Neil, C. E.
Page Count	26
Abstract	A mouse model was developed to test the hypothesis that acute exposure to high levels of chlorine (7782505) gas can increase sensitivity to inhaled antigen. The initial survey was designed to assess whether there was an increse in sensitivity to antigen and whether the effect was transient or of extended duration. BALB/c-mice were exposed to 200 or 150 parts per million (ppm) chlorine for 1 hour. The animals were then exposed to 1% aerosolized bovine serum albumin (BSA) immediately or 1, 3, 7, and 30 days after exposure. Exposures were for 30 minutes a day for 5 consecutive days. The findings indicated that in mice, acute exposure to 200ppm followed immediately by exposure to BSA resulted in increased levels of antigen specific immunoglobulin-G when compared to control values. Mice exposed acutely to lower levels of chlorine or to antigen at more distant time points following the irritant exposure did not demonstrate any increased antibody levels.
Keywords	Chlorine Immunology Mice Bovine serum albumin IgG Antigens Antibodies Exposure Lung CAS 7782-50-5
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57Y - Toxicology 57J - Immunology
Corporate Authors	Tulane Univ., New Orleans, LA. School of Medicine.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Supplemental Notes	Sponsored by National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
Title Note	Progress rept. (Final).
NTIS Issue Number	199206