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Developmental Toxicity of Boric Acid (Cas No. 10043-35-3) in CD-1-Swiss Mice. Final Report.

PB91132332

Publication Date	1989
Personal Author	Field, E. A.; Price, C. J.; Marr, M. C.; Myers, C. B.
Page Count	394
Abstract	Boric acid (BORA), widely used in manufacturing, cosmetics and pharmaceuticals, was tested for developmental toxicity in timed-mated CD-1 mice. High-dose BORA caused increased water consumption during late gestation (gd 15-17) and increased relative kidney weight. The most apparent treatment-related morphological changes involved deficient rib development at the thoracic-lumbar junction, i.e., an increased incidence of short rib XIII (a malformation) and a decreased incidence of rudimentary or full rib(s) at Lumbar I (an anatomical variation). In summary, maternal renal toxicity was observed at all BORA exposures. The low exposure (0.1%) approached the maternal no-observed-adverse effect level (NOAEL) with mild renal lesions in only 2/10 females. The NOAEL for developmental toxicity of BORA was 0.1%.
Keywords	Toxicity Boric acids Preservatives Abnormalities Ribs(Bones) Mice Reproduction(Biology) Tables(Data) Fetus Body weight Kidney Teratogens Organ weight CAS 10043-35-3
Source Agency	National Institute of Environmental Health Sciences
NTIS Subject Category	57Y - Toxicology 57S - Physiology
Corporate Authors	Research Triangle Inst., Research Triangle Park, NC.; National Toxicology Program, Research Triangle Park, NC.
Supplemental Notes	Sponsored by National Toxicology Program, Research Triangle Park, NC.
Document Type	Technical Report
Title Note	Rept. for 30 Dec 88-28 Mar 89.
NTIS Issue Number	199106

Developmental Toxicity of Boric Acid (Cas No. 10043-35-3) in CD-1-Swiss Mice. Final Report.

Developmental Toxicity of Boric Acid (Cas No. 10043-35-3) in CD-1-Swiss Mice. Final Report.
PB91132332

Publication Date	1989
Personal Author	Field, E. A.; Price, C. J.; Marr, M. C.; Myers, C. B.
Page Count	394
Abstract	Boric acid (BORA), widely used in manufacturing, cosmetics and pharmaceuticals, was tested for developmental toxicity in timed-mated CD-1 mice. High-dose BORA caused increased water consumption during late gestation (gd 15-17) and increased relative kidney weight. The most apparent treatment-related morphological changes involved deficient rib development at the thoracic-lumbar junction, i.e., an increased incidence of short rib XIII (a malformation) and a decreased incidence of rudimentary or full rib(s) at Lumbar I (an anatomical variation). In summary, maternal renal toxicity was observed at all BORA exposures. The low exposure (0.1%) approached the maternal no-observed-adverse effect level (NOAEL) with mild renal lesions in only 2/10 females. The NOAEL for developmental toxicity of BORA was 0.1%.
Keywords	Toxicity Boric acids Preservatives Abnormalities Ribs(Bones) Mice Reproduction(Biology) Tables(Data) Fetus Body weight Kidney Teratogens Organ weight CAS 10043-35-3
Source Agency	National Institute of Environmental Health Sciences
NTIS Subject Category	57Y - Toxicology 57S - Physiology
Corporate Authors	Research Triangle Inst., Research Triangle Park, NC.; National Toxicology Program, Research Triangle Park, NC.
Supplemental Notes	Sponsored by National Toxicology Program, Research Triangle Park, NC.
Document Type	Technical Report
Title Note	Rept. for 30 Dec 88-28 Mar 89.
NTIS Issue Number	199106