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Mortality among U.S. Workers Employed in the Production of Chemicals Contaminated with 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin (TCDD).

PB91125971

Publication Date	1990
Personal Author	Fingerhut, M. A.; Halperin, W. E.; Marlow, D. A.; Piacitelli, L. A.; Honchar, P. A.
Page Count	44
Abstract	A retrospective cohort mortality study was conducted of 5,172 chemical workers from 12 U.S. facilities to examine the health effects of exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (1746016) (TCDD). Occupational exposure was documented by a review of process descriptions and job duties and by measurement of serum TCDD levels in a sample of 253 workers from two of the facilities. Serum TCDD levels ranged up to 3,400 parts per trillion and were highly correlated with years worked. Mortality from several rare cancers previously associated with chemicals contaminated with TCDD was not statistically significantly elevated in the cohort: stomach; liver, biliary, passages and gallbladder; Hodgkin's Disease; non-Hodgkin's lymphoma. Mortality from soft tissue sarcoma (STS) was nonsignificantly elevated. In a subcohort of 1,520 workers with more than one year of exposure and more than 20 years of latency, STS mortality was significantly elevated (three deaths). In the same subcohort respiratory system cancer was significantly elevated. Mortality due to all cancers combined was significantly elevated in both the cohort and the subcohort.
Keywords	Mortality Chemical industry Epidemiology Blood chemical analysis Toxic substances Occupational exposure Tetrachlorodibenzodioxin Retrospective studies Carcinogenesis Cohort studies Health hazards Confounding factors
Source Agency	National Institute for Occupational Safety and Health Department H.E.W. Office of Toxic Substance and Disease
NTIS Subject Category	57U - Public Health & Industrial Medicine 44G - Environmental & Occupational Factors 94D - Job Environment
Corporate Authors	National Inst. for Occupational Safety and Health, Cincinnati, OH. Industrywide Studies Branch.; Agency for Toxic Substances and Disease Registry, Atlanta, GA.
Supplemental Notes	Sponsored by Agency for Toxic Substances and Disease Registry, Atlanta, GA.
Document Type	Technical Report
Title Note	Final rept.
NTIS Issue Number	199105

Mortality among U.S. Workers Employed in the Production of Chemicals Contaminated with 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin (TCDD).

Mortality among U.S. Workers Employed in the Production of Chemicals Contaminated with 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin (TCDD).
PB91125971

Publication Date	1990
Personal Author	Fingerhut, M. A.; Halperin, W. E.; Marlow, D. A.; Piacitelli, L. A.; Honchar, P. A.
Page Count	44
Abstract	A retrospective cohort mortality study was conducted of 5,172 chemical workers from 12 U.S. facilities to examine the health effects of exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (1746016) (TCDD). Occupational exposure was documented by a review of process descriptions and job duties and by measurement of serum TCDD levels in a sample of 253 workers from two of the facilities. Serum TCDD levels ranged up to 3,400 parts per trillion and were highly correlated with years worked. Mortality from several rare cancers previously associated with chemicals contaminated with TCDD was not statistically significantly elevated in the cohort: stomach; liver, biliary, passages and gallbladder; Hodgkin's Disease; non-Hodgkin's lymphoma. Mortality from soft tissue sarcoma (STS) was nonsignificantly elevated. In a subcohort of 1,520 workers with more than one year of exposure and more than 20 years of latency, STS mortality was significantly elevated (three deaths). In the same subcohort respiratory system cancer was significantly elevated. Mortality due to all cancers combined was significantly elevated in both the cohort and the subcohort.
Keywords	Mortality Chemical industry Epidemiology Blood chemical analysis Toxic substances Occupational exposure Tetrachlorodibenzodioxin Retrospective studies Carcinogenesis Cohort studies Health hazards Confounding factors
Source Agency	National Institute for Occupational Safety and Health Department H.E.W. Office of Toxic Substance and Disease
NTIS Subject Category	57U - Public Health & Industrial Medicine 44G - Environmental & Occupational Factors 94D - Job Environment
Corporate Authors	National Inst. for Occupational Safety and Health, Cincinnati, OH. Industrywide Studies Branch.; Agency for Toxic Substances and Disease Registry, Atlanta, GA.
Supplemental Notes	Sponsored by Agency for Toxic Substances and Disease Registry, Atlanta, GA.
Document Type	Technical Report
Title Note	Final rept.
NTIS Issue Number	199105