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Assessment of the Cocarcinogenic/Promoting Activity of Asphalt Fumes.

PB91110213

Publication Date	1989
Personal Author	Sivak, A.; Menzies, K.; Beltis, K.; Worthington, J.; Ross, A.
Page Count	254
Abstract	The carcinogenicity for mouse skin of condensed volatiles of heated asphalt (8052424) was evaluated. The possibility that either cocarcinogenic or tumor promoting activity existed in any of the chemical fractions which would account for the carcinogenic activity was investigated and an attempt was also made to identify which sets of chemical entities in the several fractions gave rise to a carcinogenic response. Volatiles from heated asphalt were collected and divided into five fractions. Fractions were applied to the skin of male C3H/HeJ-mice or Sencar-mice twice weekly for 104 weeks in proportion to the amount of the fraction in asphalt fumes. Direct carcinogenic activity was limited to two fractions: olefins, which contained alkylated aryl thiophenes and alkylated phenanthrenes; and alkylated phenylethanones and alkylated difuranones. Synergism was not observed by treatment with combined fractions. The authors conclude that, if these fractions can be further subdivided and studied, it may be possible to identify specific compounds and take more active steps toward limiting exposure at the worksite.
Keywords	Asphalts Bioassay Laboratory animals Skin cancer CAS 8052424 Polyphenyl hydrocarbons Carcinogens Thiophenes Volatile organic compounds Carcinogenesis Mortality rates Risk assessment
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57Y - Toxicology
Corporate Authors	Little (Arthur D.), Inc., Cambridge, MA.; National Inst. for Occupational Safety and Health, Cincinnati, OH. Div.
Supplemental Notes	Sponsored by National Inst. for Occupational Safety and Health, Cincinnati, OH. Div. of Biomedical and Behavioral Science.
Document Type	Technical Report
NTIS Issue Number	199102
Contract Number	PHS-200-83-2612

Assessment of the Cocarcinogenic/Promoting Activity of Asphalt Fumes.

Assessment of the Cocarcinogenic/Promoting Activity of Asphalt Fumes.
PB91110213

Publication Date	1989
Personal Author	Sivak, A.; Menzies, K.; Beltis, K.; Worthington, J.; Ross, A.
Page Count	254
Abstract	The carcinogenicity for mouse skin of condensed volatiles of heated asphalt (8052424) was evaluated. The possibility that either cocarcinogenic or tumor promoting activity existed in any of the chemical fractions which would account for the carcinogenic activity was investigated and an attempt was also made to identify which sets of chemical entities in the several fractions gave rise to a carcinogenic response. Volatiles from heated asphalt were collected and divided into five fractions. Fractions were applied to the skin of male C3H/HeJ-mice or Sencar-mice twice weekly for 104 weeks in proportion to the amount of the fraction in asphalt fumes. Direct carcinogenic activity was limited to two fractions: olefins, which contained alkylated aryl thiophenes and alkylated phenanthrenes; and alkylated phenylethanones and alkylated difuranones. Synergism was not observed by treatment with combined fractions. The authors conclude that, if these fractions can be further subdivided and studied, it may be possible to identify specific compounds and take more active steps toward limiting exposure at the worksite.
Keywords	Asphalts Bioassay Laboratory animals Skin cancer CAS 8052424 Polyphenyl hydrocarbons Carcinogens Thiophenes Volatile organic compounds Carcinogenesis Mortality rates Risk assessment
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57Y - Toxicology
Corporate Authors	Little (Arthur D.), Inc., Cambridge, MA.; National Inst. for Occupational Safety and Health, Cincinnati, OH. Div.
Supplemental Notes	Sponsored by National Inst. for Occupational Safety and Health, Cincinnati, OH. Div. of Biomedical and Behavioral Science.
Document Type	Technical Report
NTIS Issue Number	199102
Contract Number	PHS-200-83-2612