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Reproductive Toxicity of Ethylene Glycol Monomethyl Ether (CAS NO. 109-86-4) in Sprague-Dawley Rats, Litter Two.

PB90252313

Publication Date	1990
Personal Author	Gulati, D. K.; Hope, E.; Barnes, L. H.; Russell, S.; Poonacha, K. B.
Page Count	340
Abstract	Reproductive Assessment by Continuous Breeding (RACB) protocol was originally designed using mice as the test species. The purpose of the study was to develop a RACB protocol in CD Sprague-Dawley rats. Ethylene glycol monomethyl ether (EGMME), a known reproductive toxicant, was used as the test article. Dose levels selected were 0.01, 0.03, and 0.10%, administered via drinking water. In a modification of the standard protocol, male and female rats were cohabited for approximately 6 weeks, separated to allow delivery, nursing and weaning of a litter, then recohabited for approximately nine more weeks. Only one litter was born in the 0.10% dose group, and no pups were available for F1 testing. In the crossover mating, proportion of pups born alive decreased significantly in the 0.03% male X control female group.
Keywords	Toxicity Reproduction(Biology) Fertility Organic solvents Tables(Data) Ethylene glycol monomethyl ether Spermatozoa Organ weight Inbred rat strains Dose-response relationships Litter size CAS 109-86-4
Source Agency	National Institute of Environmental Health Sciences
NTIS Subject Category	57Y - Toxicology 57S - Physiology
Corporate Authors	Environmental Health Research and Testing, Inc., Lexington, KY.; National Toxicology Program, Research Triangle Park, NC.
Supplemental Notes	Portions of this document are not fully legible. Sponsored by National Toxicology Program, Research Triangle Park, NC.
Document Type	Technical Report
Title Note	Final rept.
NTIS Issue Number	199020
Contract Number	N01-ES-65142

Reproductive Toxicity of Ethylene Glycol Monomethyl Ether (CAS NO. 109-86-4) in Sprague-Dawley Rats, Litter Two.

Reproductive Toxicity of Ethylene Glycol Monomethyl Ether (CAS NO. 109-86-4) in Sprague-Dawley Rats, Litter Two.
PB90252313

Publication Date	1990
Personal Author	Gulati, D. K.; Hope, E.; Barnes, L. H.; Russell, S.; Poonacha, K. B.
Page Count	340
Abstract	Reproductive Assessment by Continuous Breeding (RACB) protocol was originally designed using mice as the test species. The purpose of the study was to develop a RACB protocol in CD Sprague-Dawley rats. Ethylene glycol monomethyl ether (EGMME), a known reproductive toxicant, was used as the test article. Dose levels selected were 0.01, 0.03, and 0.10%, administered via drinking water. In a modification of the standard protocol, male and female rats were cohabited for approximately 6 weeks, separated to allow delivery, nursing and weaning of a litter, then recohabited for approximately nine more weeks. Only one litter was born in the 0.10% dose group, and no pups were available for F1 testing. In the crossover mating, proportion of pups born alive decreased significantly in the 0.03% male X control female group.
Keywords	Toxicity Reproduction(Biology) Fertility Organic solvents Tables(Data) Ethylene glycol monomethyl ether Spermatozoa Organ weight Inbred rat strains Dose-response relationships Litter size CAS 109-86-4
Source Agency	National Institute of Environmental Health Sciences
NTIS Subject Category	57Y - Toxicology 57S - Physiology
Corporate Authors	Environmental Health Research and Testing, Inc., Lexington, KY.; National Toxicology Program, Research Triangle Park, NC.
Supplemental Notes	Portions of this document are not fully legible. Sponsored by National Toxicology Program, Research Triangle Park, NC.
Document Type	Technical Report
Title Note	Final rept.
NTIS Issue Number	199020
Contract Number	N01-ES-65142