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Experimental Pneumoconiosis of Sandblasting Substitutes.

PB90180209

Publication Date	1989
Personal Author	Hammad, Y. Y.; Abdel-Kader, H.; Bozelka, B.; Hughes, J.; Weill, H.
Page Count	36
Abstract	A study was conducted to evaluate the pulmonary fibrogenic potential of Stanblast. This substance is a sand substitute extensively used in the State of Louisiana. The study was conducted using both normal and silicotic rats. Analysis indicated that Stanblast was a complex silicate with trace amounts of several elements. Stanblast granules were milled in a ball mill to produced dust for animal exposures. Male rats were exposed by inhalation in a horizontal laminar flow whole body exposure chamber to 10.8 milligrams of the Stanblast dust/cubic meter, 6 hours a day, 5 days a week for 1 year. Rats were killed 6 to 24 months after the start of exposure, and lungs were examined. Histologic examinations of the exposed lungs revealed the presence of microgranulomas throughout the lung fields, suggesting the release of certain cellular modifying agents. The absence of any obvious collagen deposition within the structures of the surrounding interstitium indicated a lack of fibrogenic potential for Stanblast under the conditions of the experiment. The lack of significant difference in hydroxyproline content of the lungs of exposed and control rats corroborated the histologic conclusions.
Keywords	Pneumoconiosis Abrasive blasting Toxicity Occupational diseases Rats Lung Pathology Graphs(Charts) Tables(Data) Hydroxyproline Organ weight
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57E - Clinical Medicine 57Y - Toxicology 44G - Environmental & Occupational Factors
Corporate Authors	Tulane Univ., New Orleans, LA. School of Medicine.
Document Type	Technical Report
NTIS Issue Number	199010

Experimental Pneumoconiosis of Sandblasting Substitutes.

Experimental Pneumoconiosis of Sandblasting Substitutes.
PB90180209

Publication Date	1989
Personal Author	Hammad, Y. Y.; Abdel-Kader, H.; Bozelka, B.; Hughes, J.; Weill, H.
Page Count	36
Abstract	A study was conducted to evaluate the pulmonary fibrogenic potential of Stanblast. This substance is a sand substitute extensively used in the State of Louisiana. The study was conducted using both normal and silicotic rats. Analysis indicated that Stanblast was a complex silicate with trace amounts of several elements. Stanblast granules were milled in a ball mill to produced dust for animal exposures. Male rats were exposed by inhalation in a horizontal laminar flow whole body exposure chamber to 10.8 milligrams of the Stanblast dust/cubic meter, 6 hours a day, 5 days a week for 1 year. Rats were killed 6 to 24 months after the start of exposure, and lungs were examined. Histologic examinations of the exposed lungs revealed the presence of microgranulomas throughout the lung fields, suggesting the release of certain cellular modifying agents. The absence of any obvious collagen deposition within the structures of the surrounding interstitium indicated a lack of fibrogenic potential for Stanblast under the conditions of the experiment. The lack of significant difference in hydroxyproline content of the lungs of exposed and control rats corroborated the histologic conclusions.
Keywords	Pneumoconiosis Abrasive blasting Toxicity Occupational diseases Rats Lung Pathology Graphs(Charts) Tables(Data) Hydroxyproline Organ weight
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57E - Clinical Medicine 57Y - Toxicology 44G - Environmental & Occupational Factors
Corporate Authors	Tulane Univ., New Orleans, LA. School of Medicine.
Document Type	Technical Report
NTIS Issue Number	199010