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NIOSH (National Institute for Occupational Safety and Health) Testimony to DOL (Department of Labor) on Benzene and Leukemia: An Epidemiologic Risk Assessment to the Occupational Safety and Health Administration by J. D. Millar, August 9, 1985.

PB90153776

Publication Date	1985
Personal Author	Rinsky, R. A.; Smith, A. B.; Hornung, R.; Filloon, T. G.; Young, R. J.
Page Count	47
Abstract	In the testimony, the mortality experience of a cohort with occupational exposure to benzene (71432) was updated to learn more about a possible connection to leukemia. Job/exposure matrices were used to derive cumulative exposure concentrations. The matrices were based on available air sampling data. The standardized mortality ratio (SMR) for leukemia was 328 and the SMR for multiple myeloma was 298. SMRs for leukemia increased from 105 in workers with less than 40 part per million years (ppm/y) cumulative exposure to 314 in workers with from 40 to 199.99 ppm/y; to 1,757 in those with from 200 to 399.99 ppm/y; and to 4,535 in those with 400 ppm/y or more. A 40-year working lifetime exposure at 10 parts per million was equivalent to a cumulative benzene exposure of 400 ppm/y. When the boundaries of the exposure categories were varied, this strongly positive trend in SMRs remained evident. A conditional logistic regression was performed to examine the shape of the exposure/response relation. A log linear model best explained the association between cumulative benzene exposure and leukemia. It was calculated from the model that protection against benzene induced leukemia will be increased exponentially by any reduction in the permissible exposure limit.
Keywords	Benzene Leukemia Mortality Epidemiology Risk Carcinogens Toxicity Occupational exposure Dose response relationships Testimony Maximum permissible exposure level CAS 71-43-2
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57U - Public Health & Industrial Medicine 41I - Job Environment 94D - Job Environment 68G - Environmental Health & Safety 44G - Environmental & Occupational Factors
Corporate Authors	National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
NTIS Issue Number	199009

NIOSH (National Institute for Occupational Safety and Health) Testimony to DOL (Department of Labor) on Benzene and Leukemia: An Epidemiologic Risk Assessment to the Occupational Safety and Health Administration by J. D. Millar, August 9, 1985.

NIOSH (National Institute for Occupational Safety and Health) Testimony to DOL (Department of Labor) on Benzene and Leukemia: An Epidemiologic Risk Assessment to the Occupational Safety and Health Administration by J. D. Millar, August 9, 1985.
PB90153776

Publication Date	1985
Personal Author	Rinsky, R. A.; Smith, A. B.; Hornung, R.; Filloon, T. G.; Young, R. J.
Page Count	47
Abstract	In the testimony, the mortality experience of a cohort with occupational exposure to benzene (71432) was updated to learn more about a possible connection to leukemia. Job/exposure matrices were used to derive cumulative exposure concentrations. The matrices were based on available air sampling data. The standardized mortality ratio (SMR) for leukemia was 328 and the SMR for multiple myeloma was 298. SMRs for leukemia increased from 105 in workers with less than 40 part per million years (ppm/y) cumulative exposure to 314 in workers with from 40 to 199.99 ppm/y; to 1,757 in those with from 200 to 399.99 ppm/y; and to 4,535 in those with 400 ppm/y or more. A 40-year working lifetime exposure at 10 parts per million was equivalent to a cumulative benzene exposure of 400 ppm/y. When the boundaries of the exposure categories were varied, this strongly positive trend in SMRs remained evident. A conditional logistic regression was performed to examine the shape of the exposure/response relation. A log linear model best explained the association between cumulative benzene exposure and leukemia. It was calculated from the model that protection against benzene induced leukemia will be increased exponentially by any reduction in the permissible exposure limit.
Keywords	Benzene Leukemia Mortality Epidemiology Risk Carcinogens Toxicity Occupational exposure Dose response relationships Testimony Maximum permissible exposure level CAS 71-43-2
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57U - Public Health & Industrial Medicine 41I - Job Environment 94D - Job Environment 68G - Environmental Health & Safety 44G - Environmental & Occupational Factors
Corporate Authors	National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
NTIS Issue Number	199009