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NIOSH (National Institute for Occupational Safety and Health) Testimony on Ethylene Dichloride and 2,4-Diaminoanisole Before the Subcommittee on Oversight and Investigations, House Committee on Interstate and Foreign Commerce, by Edward J. Baier, January 23, 1978.

PB90131103

Publication Date	1978
Page Count	12
Abstract	The statement reviewed the role of the National Institute for Occupational Safety and Health (NIOSH) in investigating ethylene-dichloride (107062) (EDC) and 2,4-diaminoanisole (615054) (DA). In 1976 a criteria documents suggested the standard for exposure to EDC be set at 5 parts per million (ppm) based on reports of adverse effects on the nervous system and livers of workers exposed to 10 to 15 ppm EDC. Higher exposure levels were apparently related to cardiac and respiratory system effects. Nursing mothers were advised not to work with EDC as it could be carried in their milk. Subsequently reports were made of excessive tumors occurring in laboratory mice and rats fed EDC for 78 weeks. In January of 1978 NIOSH issued a Current Intelligence Bulletin recommending that DA and its salts be handled as though they were human carcinogens. Two epidemiologic studies have been reported where excessive cancer has been diagnosed among cosmetologists. One study suggested excessive genital cancer and the other suggested excessive cancer in several organ systems. Other reports indicated mutagenic potential in bacterial systems and in the fruit fly. NIOSH recommended that skin exposure be limited and that engineering and work practice controls be made more stringent.
Keywords	Industrial medicine Anisole Exposure Toxicity Inspection Hazardous materials Carcinogens Dyes Toxic substances Occupational safety and health Ethylene dichlorides CAS 107-06-2 CAS 615-05-4 Testimony
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57U - Public Health & Industrial Medicine 57Y - Toxicology 94D - Job Environment 41I - Job Environment 68G - Environmental Health & Safety
Corporate Authors	National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
NTIS Issue Number	199006

NIOSH (National Institute for Occupational Safety and Health) Testimony on Ethylene Dichloride and 2,4-Diaminoanisole Before the Subcommittee on Oversight and Investigations, House Committee on Interstate and Foreign Commerce, by Edward J. Baier, January 23, 1978.

NIOSH (National Institute for Occupational Safety and Health) Testimony on Ethylene Dichloride and 2,4-Diaminoanisole Before the Subcommittee on Oversight and Investigations, House Committee on Interstate and Foreign Commerce, by Edward J. Baier, January 23, 1978.
PB90131103

Publication Date	1978
Page Count	12
Abstract	The statement reviewed the role of the National Institute for Occupational Safety and Health (NIOSH) in investigating ethylene-dichloride (107062) (EDC) and 2,4-diaminoanisole (615054) (DA). In 1976 a criteria documents suggested the standard for exposure to EDC be set at 5 parts per million (ppm) based on reports of adverse effects on the nervous system and livers of workers exposed to 10 to 15 ppm EDC. Higher exposure levels were apparently related to cardiac and respiratory system effects. Nursing mothers were advised not to work with EDC as it could be carried in their milk. Subsequently reports were made of excessive tumors occurring in laboratory mice and rats fed EDC for 78 weeks. In January of 1978 NIOSH issued a Current Intelligence Bulletin recommending that DA and its salts be handled as though they were human carcinogens. Two epidemiologic studies have been reported where excessive cancer has been diagnosed among cosmetologists. One study suggested excessive genital cancer and the other suggested excessive cancer in several organ systems. Other reports indicated mutagenic potential in bacterial systems and in the fruit fly. NIOSH recommended that skin exposure be limited and that engineering and work practice controls be made more stringent.
Keywords	Industrial medicine Anisole Exposure Toxicity Inspection Hazardous materials Carcinogens Dyes Toxic substances Occupational safety and health Ethylene dichlorides CAS 107-06-2 CAS 615-05-4 Testimony
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57U - Public Health & Industrial Medicine 57Y - Toxicology 94D - Job Environment 41I - Job Environment 68G - Environmental Health & Safety
Corporate Authors	National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
NTIS Issue Number	199006