National Technical Reports Library

The National Technical Information Service acquires, indexes, abstracts, and archives the largest collection of U.S. government-sponsored technical reports in existence. The NTRL offers online, free and open access to these authenticated government technical reports. Technical reports and documents in its repository may be available online for free either from the issuing federal agency, the U.S. Government Publishing Office’s Federal Digital System website, or through search engines.

Details

Dose-Effect Relationship of Asbestos Dust.

PB90129859

Publication Date	1972
Personal Author	Gross, P.
Page Count	18
Abstract	The pulmonary concentration of asbestos (1332214) dust was determined in rats which had inhaled asbestos dust or had been injected with this dust. Particular attention was given to the pulmonary concentration of asbestos dust in rats with cancer. This was compared to the amount of asbestos dust concentrated in the lungs of rats without cancer. A comparison was also made of the dust concentration in the lungs of rats where lung clearance was impaired and in rats with presumably normal clearance. The silica (14808607) content of the lungs of rats that had inhaled high concentrations of asbestos over a 16-month period was extremely low. The differences in the silica content between groups that had lung cancer and those that had no lung cancer was small. No group showed a decisive difference in pulmonary silica content. The lungs used in the study had been stored in formaldehyde solution for 5 to 6 years prior to analysis. Results indicated that lung tissue containing deposits of finely divided chrysotile dust may lose this dust by dissolution if kept submerged in aqueous formaldehyde solution for a prolonged period. The study recommends that asbestos determinations should be made on fresh lung tissue or on lung tissue that has been fume fixed after removal from the body and dried.
Keywords	Asbestos Dust Toxicology Serpentine Rats Lung neoplasms Lung Tables(Data) Silicon oxide Dose-response relationships Air pollution effects(Animals) CAS 1332-21-4 CAS 14808-60-7
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57Y - Toxicology 68A - Air Pollution & Control
Corporate Authors	Industrial Health Foundation, Inc., Pittsburgh, PA.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Supplemental Notes	Sponsored by National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
Title Note	Technical rept. (Final).
NTIS Issue Number	199004

Dose-Effect Relationship of Asbestos Dust.

Dose-Effect Relationship of Asbestos Dust.
PB90129859

Publication Date	1972
Personal Author	Gross, P.
Page Count	18
Abstract	The pulmonary concentration of asbestos (1332214) dust was determined in rats which had inhaled asbestos dust or had been injected with this dust. Particular attention was given to the pulmonary concentration of asbestos dust in rats with cancer. This was compared to the amount of asbestos dust concentrated in the lungs of rats without cancer. A comparison was also made of the dust concentration in the lungs of rats where lung clearance was impaired and in rats with presumably normal clearance. The silica (14808607) content of the lungs of rats that had inhaled high concentrations of asbestos over a 16-month period was extremely low. The differences in the silica content between groups that had lung cancer and those that had no lung cancer was small. No group showed a decisive difference in pulmonary silica content. The lungs used in the study had been stored in formaldehyde solution for 5 to 6 years prior to analysis. Results indicated that lung tissue containing deposits of finely divided chrysotile dust may lose this dust by dissolution if kept submerged in aqueous formaldehyde solution for a prolonged period. The study recommends that asbestos determinations should be made on fresh lung tissue or on lung tissue that has been fume fixed after removal from the body and dried.
Keywords	Asbestos Dust Toxicology Serpentine Rats Lung neoplasms Lung Tables(Data) Silicon oxide Dose-response relationships Air pollution effects(Animals) CAS 1332-21-4 CAS 14808-60-7
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57Y - Toxicology 68A - Air Pollution & Control
Corporate Authors	Industrial Health Foundation, Inc., Pittsburgh, PA.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Supplemental Notes	Sponsored by National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
Title Note	Technical rept. (Final).
NTIS Issue Number	199004