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Manganese Poisoning: A Metabolic Disorder, Final Report on Research Project.

PB90115106

Publication Date	1974
Personal Author	Mena, I.
Page Count	31
Abstract	Study of the clinical and metabolic aspects of manganese poisoning findings include: levodopa is capable of correcting symptoms of extrapyramidal damage induced by manganese; susceptibility to manganese poisoning is linked to increased intestinal absorption of manganese in anemic individuals, with a positive correlation demonstrated for iron and manganese absorption; parallel pathophysiology is found between manganese poisoning and Parkinson's disease. Other areas of investigation include: long term treatment of manganic patients, mechanism for intermittent loss of control and involuntary movements induced by levodopa, and study of interaction of manganese and dopa and permeability of blood brain barrier to manganese.
Keywords	Manganese Toxic diseases Metabolic diseases Blood chemical analysis Somatotropin Parkinsons disease Catecholamines Nervous system disorders Tables(Data) Intestinal absorption Levodopa Blood-brain barrier Symptomatic Parkinson disease Disease susceptibility
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57Y - Toxicology 57E - Clinical Medicine 57Q - Pharmacology & Pharmacological Chemistry
Corporate Authors	Pontificia Univ. Catolica de Chile, Santiago.; Brookhaven National Lab., Upton, NY.; Pan American Health Organization, Washington, DC.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Supplemental Notes	See also PB90-115098. Prepared in cooperation with Brookhaven National Lab., Upton, NY., and Pan American Health Organization, Washington, DC. Sponsored by National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
NTIS Issue Number	199003

Manganese Poisoning: A Metabolic Disorder, Final Report on Research Project.

Manganese Poisoning: A Metabolic Disorder, Final Report on Research Project.
PB90115106

Publication Date	1974
Personal Author	Mena, I.
Page Count	31
Abstract	Study of the clinical and metabolic aspects of manganese poisoning findings include: levodopa is capable of correcting symptoms of extrapyramidal damage induced by manganese; susceptibility to manganese poisoning is linked to increased intestinal absorption of manganese in anemic individuals, with a positive correlation demonstrated for iron and manganese absorption; parallel pathophysiology is found between manganese poisoning and Parkinson's disease. Other areas of investigation include: long term treatment of manganic patients, mechanism for intermittent loss of control and involuntary movements induced by levodopa, and study of interaction of manganese and dopa and permeability of blood brain barrier to manganese.
Keywords	Manganese Toxic diseases Metabolic diseases Blood chemical analysis Somatotropin Parkinsons disease Catecholamines Nervous system disorders Tables(Data) Intestinal absorption Levodopa Blood-brain barrier Symptomatic Parkinson disease Disease susceptibility
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57Y - Toxicology 57E - Clinical Medicine 57Q - Pharmacology & Pharmacological Chemistry
Corporate Authors	Pontificia Univ. Catolica de Chile, Santiago.; Brookhaven National Lab., Upton, NY.; Pan American Health Organization, Washington, DC.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Supplemental Notes	See also PB90-115098. Prepared in cooperation with Brookhaven National Lab., Upton, NY., and Pan American Health Organization, Washington, DC. Sponsored by National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
NTIS Issue Number	199003