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Synthesis and Identification of Highly Toxic Polybrominated Biphenyls in the Fire Retardant FireMaster BP-6.

PB90106238

Publication Date	1984
Personal Author	Robertson, L. W.; Safe, S. H.; Parkinson, A.; Pellizzari, E.; Pochini, C.
Page Count	8
Abstract	The accidental substitution of fireMaster, a commercial polybrominated biphenyl (PBB) flame retardant, for nutriMaster, a magnesium oxide cattle feed supplement, resulted in a major pollution disaster that was primarily confined to the State of Michigan. The initial contamination of cattle and related agricultural products ultimately resulted in the widespread contamination of the food chain within the state. The identity of over 91% of the polybrominated biphenyl (PBB) components present in fireMaster BP-6 was determined by capillary gas chromatography (GC) and GC-mass spectrometry (MS) with 22 individual PBB congeners as reference standards. There was an excellent correlation between the observed retention times of the individual PBBs (and of the corresponding GC peaks in fireMaster) and the expected retention times calculated from the degree of bromination and substituent orientation for the PBB standards. Previous studies indicate that the more toxic PBBs are also inducers of rat hepatic microsomal aryl hydrocarbon hydroxylas (AHH). The paper reports that GC and HV-MS identification of seven additional PBBs in fireMaster that also induce aryl hydrocarbon hydroxylas. Included in the group of seven potentially toxic PBBs are the coplanar 3,3', 4',4'-tetra-,3,3-,3,3-,5-penta-, and 3,3-,4,4-,5,5'-hexabromobiphenyls, which represent the most toxic group of PBB congeners identified in fireMaster. (Copyright (c) 1984 American Chemical Society.)
Keywords	Fire resistant materials Toxicity Mass spectroscopy Synthesis(Chemistry) Reprints Polybrominated biphenyls Gas chromatography
Source Agency	Environmental Protection Agency Office of Research and Development
NTIS Subject Category	57Y - Toxicology 57B - Biochemistry
Corporate Authors	Environmental Research Lab.-Duluth, Grosse Ile, MI. Large Lakes Research Station.; Texas A and M Univ., College Station.; Research Triangle Inst., Research Triangle Park, NC.; ROCOM, Montclair, NJ.
Supplemental Notes	Pub. in Jnl. of Agricultural and Food Chemistry, v32, p1107-1111, 1984. Prepared in cooperation with Texas A and M Univ., College Station, ROCOM, Montclair, NJ., and Research Triangle Inst., Research Triangle Park, NC.
Document Type	Journal Article
Title Note	Journal article.
NTIS Issue Number	199001

Synthesis and Identification of Highly Toxic Polybrominated Biphenyls in the Fire Retardant FireMaster BP-6.

Synthesis and Identification of Highly Toxic Polybrominated Biphenyls in the Fire Retardant FireMaster BP-6.
PB90106238

Publication Date	1984
Personal Author	Robertson, L. W.; Safe, S. H.; Parkinson, A.; Pellizzari, E.; Pochini, C.
Page Count	8
Abstract	The accidental substitution of fireMaster, a commercial polybrominated biphenyl (PBB) flame retardant, for nutriMaster, a magnesium oxide cattle feed supplement, resulted in a major pollution disaster that was primarily confined to the State of Michigan. The initial contamination of cattle and related agricultural products ultimately resulted in the widespread contamination of the food chain within the state. The identity of over 91% of the polybrominated biphenyl (PBB) components present in fireMaster BP-6 was determined by capillary gas chromatography (GC) and GC-mass spectrometry (MS) with 22 individual PBB congeners as reference standards. There was an excellent correlation between the observed retention times of the individual PBBs (and of the corresponding GC peaks in fireMaster) and the expected retention times calculated from the degree of bromination and substituent orientation for the PBB standards. Previous studies indicate that the more toxic PBBs are also inducers of rat hepatic microsomal aryl hydrocarbon hydroxylas (AHH). The paper reports that GC and HV-MS identification of seven additional PBBs in fireMaster that also induce aryl hydrocarbon hydroxylas. Included in the group of seven potentially toxic PBBs are the coplanar 3,3', 4',4'-tetra-,3,3-,3,3-,5-penta-, and 3,3-,4,4-,5,5'-hexabromobiphenyls, which represent the most toxic group of PBB congeners identified in fireMaster. (Copyright (c) 1984 American Chemical Society.)
Keywords	Fire resistant materials Toxicity Mass spectroscopy Synthesis(Chemistry) Reprints Polybrominated biphenyls Gas chromatography
Source Agency	Environmental Protection Agency Office of Research and Development
NTIS Subject Category	57Y - Toxicology 57B - Biochemistry
Corporate Authors	Environmental Research Lab.-Duluth, Grosse Ile, MI. Large Lakes Research Station.; Texas A and M Univ., College Station.; Research Triangle Inst., Research Triangle Park, NC.; ROCOM, Montclair, NJ.
Supplemental Notes	Pub. in Jnl. of Agricultural and Food Chemistry, v32, p1107-1111, 1984. Prepared in cooperation with Texas A and M Univ., College Station, ROCOM, Montclair, NJ., and Research Triangle Inst., Research Triangle Park, NC.
Document Type	Journal Article
Title Note	Journal article.
NTIS Issue Number	199001