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Estimation of HIV (Human Immunodeficiency Virus) and HBV (Hepatitis-B Virus) Infectious Titers in Human Fluids and Tissues.


PB90103334

Publication Date 1989
Personal Author Strauss, H.; Hattis, D.
Page Count 52
Abstract A four task project was conducted to assess the risks of human immunodeficiency virus (HIV) and hepatitis-B virus (HBV) infection for health care workers. This was the first of the tasks and includes a basic biological description of the two viruses and assess the available information on the distribution of infectious titers in the patients that might be sources of occupational exposure. Two potential vectors of occupational infection were cited: free viral particles and infected cells. Data concerning the distribution of HIV antigen titers in blood suggested that symptomatic stages of HIV infection are associated with increased median titers of free virus and reduced variability in viral titers. One set of serial dilution measurements interpreted in terms of distributions of cell mediated infectious titers for one specific population group, asymptomatic seropositive people, indicated that the median cellular infectious titer for this group may exceed the titer due to free viral particles by approximately 500 times. The authors conclude that a comparison of these data with the HIV titer data helps explain the much greater frequency of occupational transmission for HBV than for HIV.
Keywords
  • Epidemiology
  • Disease vectors
  • Medical personnel
  • Tables(Data)
  • Graphs(Charts)
  • Tissues(Biology)
  • Body fluids
  • Cells(Biology)
  • Acquired immunodeficiency syndrome(AIDS)
  • Hepatitis B
  • Occupational exposure
  • Human immunodeficiency virus(HIV)
  • Risk assessment
  • Virion
Source Agency
  • National Institute for Occupational Safety and Health
NTIS Subject Category
  • 57E - Clinical Medicine
  • 57D - Clinical Chemistry
  • 57U - Public Health & Industrial Medicine
Corporate Authors Massachusetts Inst. of Tech., Cambridge. Center for Technology, Policy and Industrial Development.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Supplemental Notes Sponsored by National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type Technical Report
NTIS Issue Number 199001
Estimation of HIV (Human Immunodeficiency Virus) and HBV (Hepatitis-B Virus) Infectious Titers in Human Fluids and Tissues.
Estimation of HIV (Human Immunodeficiency Virus) and HBV (Hepatitis-B Virus) Infectious Titers in Human Fluids and Tissues.
PB90103334

  • Epidemiology
  • Disease vectors
  • Medical personnel
  • Tables(Data)
  • Graphs(Charts)
  • Tissues(Biology)
  • Body fluids
  • Cells(Biology)
  • Acquired immunodeficiency syndrome(AIDS)
  • Hepatitis B
  • Occupational exposure
  • Human immunodeficiency virus(HIV)
  • Risk assessment
  • Virion
  • National Institute for Occupational Safety and Health
  • 57E - Clinical Medicine
  • 57D - Clinical Chemistry
  • 57U - Public Health & Industrial Medicine
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