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Information Profiles on Potential Occupational Hazards: Epoxy Compounds (non-cyclic).

PB89216634

Publication Date	1982
Page Count	128
Abstract	Information profiles are presented for these epoxy compounds: n-alkyl-glycidyl-ethers, allyl-glycidyl-ether (106923), 1,2-butylene-oxide (106887), butyl-glycidyl-ether (2426086), 1,2-epoxyhexadecane (7320378), ethylene-oxide (75218), 2-ethylhexyl-glycidyl-ether (2461156), glycidol (556525), glycidyl-acrylate (106901), glycidyl-methacrylate (106912), and propylene-oxide (75569). The median lethal toxicity value in rats for these compounds ranged from 232 mg/kg for glycidyl-acrylate to 17100 mg/kg for n-alkyl-glycidyl. Most of the compounds were mild to moderate skin and eye irritants. Ethylene-oxide was shown to be teratogenic in mice when given by intravenous injection, but not in rats exposed by inhalation. Several of these compounds demonstrated positive mutagenic responses. Butylene-oxide and glycidyl-methacrylate caused no increase in tumors after administered dermally and by gavage, respectively. Ethylene-oxide demonstrated a weak positive response in a carcinogenicity bioassay. A positive carcinogenic result was obtained for 1,2-epoxyhexadecane in a skin painting study. Propylene-oxide produced tumors at the site of injection following subcutaneous administration.
Keywords	Industrial medicine Epoxy compounds Exposure Toxicity Lethal dosage Chemical analysis Utilization Control equipment Production Occupational safety and health Toxic substances Biological effects CAS 106-92-3 CAS 106-88-7 CAS 2426-08-6 CAS 7320-37-8 CAS 75-21-8 CAS 2461-15-6 CAS 556-52-5 CAS 106-90-1 CAS 106-91-2 CAS 75-56-9
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57U - Public Health & Industrial Medicine 57Y - Toxicology 41I - Job Environment 94D - Job Environment 68G - Environmental Health & Safety
Corporate Authors	Syracuse Research Corp., NY. Center for Chemical Hazard Assessment.; National Inst. for Occupational Safety and Health, Rockville, MD.
Supplemental Notes	Sponsored by National Inst. for Occupational Safety and Health, Rockville, MD.
Document Type	Technical Report
Title Note	Draft rept. (Second).
NTIS Issue Number	198921
Contract Number	PHS-NIOSH-210-79-0030

Information Profiles on Potential Occupational Hazards: Epoxy Compounds (non-cyclic).

Information Profiles on Potential Occupational Hazards: Epoxy Compounds (non-cyclic).
PB89216634

Publication Date	1982
Page Count	128
Abstract	Information profiles are presented for these epoxy compounds: n-alkyl-glycidyl-ethers, allyl-glycidyl-ether (106923), 1,2-butylene-oxide (106887), butyl-glycidyl-ether (2426086), 1,2-epoxyhexadecane (7320378), ethylene-oxide (75218), 2-ethylhexyl-glycidyl-ether (2461156), glycidol (556525), glycidyl-acrylate (106901), glycidyl-methacrylate (106912), and propylene-oxide (75569). The median lethal toxicity value in rats for these compounds ranged from 232 mg/kg for glycidyl-acrylate to 17100 mg/kg for n-alkyl-glycidyl. Most of the compounds were mild to moderate skin and eye irritants. Ethylene-oxide was shown to be teratogenic in mice when given by intravenous injection, but not in rats exposed by inhalation. Several of these compounds demonstrated positive mutagenic responses. Butylene-oxide and glycidyl-methacrylate caused no increase in tumors after administered dermally and by gavage, respectively. Ethylene-oxide demonstrated a weak positive response in a carcinogenicity bioassay. A positive carcinogenic result was obtained for 1,2-epoxyhexadecane in a skin painting study. Propylene-oxide produced tumors at the site of injection following subcutaneous administration.
Keywords	Industrial medicine Epoxy compounds Exposure Toxicity Lethal dosage Chemical analysis Utilization Control equipment Production Occupational safety and health Toxic substances Biological effects CAS 106-92-3 CAS 106-88-7 CAS 2426-08-6 CAS 7320-37-8 CAS 75-21-8 CAS 2461-15-6 CAS 556-52-5 CAS 106-90-1 CAS 106-91-2 CAS 75-56-9
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57U - Public Health & Industrial Medicine 57Y - Toxicology 41I - Job Environment 94D - Job Environment 68G - Environmental Health & Safety
Corporate Authors	Syracuse Research Corp., NY. Center for Chemical Hazard Assessment.; National Inst. for Occupational Safety and Health, Rockville, MD.
Supplemental Notes	Sponsored by National Inst. for Occupational Safety and Health, Rockville, MD.
Document Type	Technical Report
Title Note	Draft rept. (Second).
NTIS Issue Number	198921
Contract Number	PHS-NIOSH-210-79-0030