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Information Profiles on Potential Occupational Hazards: Organic Anhydrides.


PB89216618

Publication Date 1982
Page Count 132
Abstract Information profiles are presented on these organic anhydrides: acetic-anhydride (108247), butyric-anhydride (106310), citraconic-anhydride (616024), dodecenylsuccinic-anhydride (25377735), isobutyric-anhydride (97723), maleic-anhydride (108316), phthalic-anhydride (85449), propionic-anhydride (123626), pyromellitic-dianhydride (89327), succinic-anhydride (108305), tetrahydrophthalic-anhydride (85438), and trimellitic-anhydride (552307). The organic anhydrides appear to be moderately toxic with median lethal dose levels for rats ranging from 697 to 2600 mg/kg. The maleic, phthalic, acetic and trimellitic anhydrides appear to be the most acutely toxic of the group discussed. All were irritants to the skin, eyes, and respiratory tract. Injection site tumors have occurred following administration of succinic and maleic anhydrides. Limited evidence suggests teratogenic potentials for acetic, maleic, phthalic, and succinic anhydrides.
Keywords
  • Industrial medicine
  • Anhydrides
  • Exposure
  • Toxicity
  • Chemical analysis
  • Production
  • Utilization
  • Control equipment
  • Occupational safety and health
  • Toxic substances
  • Biological effects
  • CAS 108-24-7
  • CAS 106-31-0
  • CAS 616-02-4
  • CAS 25377-73-5
  • CAS 97-72-3
  • CAS 108-31-6
  • CAS 85-44-9
  • CAS 123-62-6
  • CAS 89-32-7
  • CAS 108-30-5
  • CAS 85-43-8
  • CAS 552-30-7
Source Agency
  • National Institute for Occupational Safety and Health
NTIS Subject Category
  • 57U - Public Health & Industrial Medicine
  • 57Y - Toxicology
  • 41I - Job Environment
  • 94D - Job Environment
  • 68G - Environmental Health & Safety
Corporate Authors Syracuse Research Corp., NY. Center for Chemical Hazard Assessment.; National Inst. for Occupational Safety and Health, Rockville, MD.
Supplemental Notes Sponsored by National Inst. for Occupational Safety and Health, Rockville, MD.
Document Type Technical Report
Title Note Draft rept. (Second).
NTIS Issue Number 198921
Contract Number
  • PHS-NIOSH-210-79-0030
Information Profiles on Potential Occupational Hazards: Organic Anhydrides.
Information Profiles on Potential Occupational Hazards: Organic Anhydrides.
PB89216618

  • Industrial medicine
  • Anhydrides
  • Exposure
  • Toxicity
  • Chemical analysis
  • Production
  • Utilization
  • Control equipment
  • Occupational safety and health
  • Toxic substances
  • Biological effects
  • CAS 108-24-7
  • CAS 106-31-0
  • CAS 616-02-4
  • CAS 25377-73-5
  • CAS 97-72-3
  • CAS 108-31-6
  • CAS 85-44-9
  • CAS 123-62-6
  • CAS 89-32-7
  • CAS 108-30-5
  • CAS 85-43-8
  • CAS 552-30-7
  • National Institute for Occupational Safety and Health
  • 57U - Public Health & Industrial Medicine
  • 57Y - Toxicology
  • 41I - Job Environment
  • 94D - Job Environment
  • 68G - Environmental Health & Safety
  • PHS-NIOSH-210-79-0030
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