Abstract |
Information profiles are presented on these organic anhydrides: acetic-anhydride (108247), butyric-anhydride (106310), citraconic-anhydride (616024), dodecenylsuccinic-anhydride (25377735), isobutyric-anhydride (97723), maleic-anhydride (108316), phthalic-anhydride (85449), propionic-anhydride (123626), pyromellitic-dianhydride (89327), succinic-anhydride (108305), tetrahydrophthalic-anhydride (85438), and trimellitic-anhydride (552307). The organic anhydrides appear to be moderately toxic with median lethal dose levels for rats ranging from 697 to 2600 mg/kg. The maleic, phthalic, acetic and trimellitic anhydrides appear to be the most acutely toxic of the group discussed. All were irritants to the skin, eyes, and respiratory tract. Injection site tumors have occurred following administration of succinic and maleic anhydrides. Limited evidence suggests teratogenic potentials for acetic, maleic, phthalic, and succinic anhydrides. |