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PB89216543

Publication Date	1989
Personal Author	Abdo, K.
Page Count	200
Abstract	Two-year toxicology and carcinogenesis studies were conducted by administering diets containing 0, 50, or 100 ppm roxarsone to groups of 50 rats of each sex. Diets containing 0, 100, or 200 ppm were fed to groups of 50 mice of each sex. Under the conditions of the studies, there was equivocal evidence of carcinogenic activity of roxarsone for male F344/N rats, as indicated by a marginally increased incidence of adenomas of the exocrine pancreas. There was no evidence of carcinogenic activity for female F344/N rats fed diets containing 50 or 100 ppm roxarsone for 2 years. There was no evidence of carcinogenic activity for male or female B6C3F1 mice fed diets containing 100 or 200 ppm roxarsone for 2 years.
Keywords	Toxicology Drugs Public health Arsenic organic compounds Tables(Data) Bioassay Exposure Mice Rats Laboratory animals Carcinogenesis Toxic substances Roxarsone Dose-response relationships CAS 121-19-7
Source Agency	National Institute of Environmental Health Sciences
NTIS Subject Category	57Y - Toxicology 57U - Public Health & Industrial Medicine 68G - Environmental Health & Safety
Corporate Authors	National Toxicology Program, Research Triangle Park, NC.
Document Type	Technical Report
Title Note	Technical rept. series.
NTIS Issue Number	198921

Toxicology and Carcinogenesis Studies of Roxarsone (Cas No. 121-19-7) in F344/N Rats and B6C3F1 Mice (Feed Studies).

Toxicology and Carcinogenesis Studies of Roxarsone (Cas No. 121-19-7) in F344/N Rats and B6C3F1 Mice (Feed Studies).
PB89216543

Publication Date	1989
Personal Author	Abdo, K.
Page Count	200
Abstract	Two-year toxicology and carcinogenesis studies were conducted by administering diets containing 0, 50, or 100 ppm roxarsone to groups of 50 rats of each sex. Diets containing 0, 100, or 200 ppm were fed to groups of 50 mice of each sex. Under the conditions of the studies, there was equivocal evidence of carcinogenic activity of roxarsone for male F344/N rats, as indicated by a marginally increased incidence of adenomas of the exocrine pancreas. There was no evidence of carcinogenic activity for female F344/N rats fed diets containing 50 or 100 ppm roxarsone for 2 years. There was no evidence of carcinogenic activity for male or female B6C3F1 mice fed diets containing 100 or 200 ppm roxarsone for 2 years.
Keywords	Toxicology Drugs Public health Arsenic organic compounds Tables(Data) Bioassay Exposure Mice Rats Laboratory animals Carcinogenesis Toxic substances Roxarsone Dose-response relationships CAS 121-19-7
Source Agency	National Institute of Environmental Health Sciences
NTIS Subject Category	57Y - Toxicology 57U - Public Health & Industrial Medicine 68G - Environmental Health & Safety
Corporate Authors	National Toxicology Program, Research Triangle Park, NC.
Document Type	Technical Report
Title Note	Technical rept. series.
NTIS Issue Number	198921