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Information Profiles on Potential Occupational Hazards: Nitrophenols.


PB89215842

Publication Date 1981
Page Count 82
Abstract Information profiles are presented for the following nitrophenols: 2-nitrophenol (88755), 3-nitrophenol (554847), 4-nitrophenol (100027), 2,4-dinitrophenol (51285), and 2,4,6-trinitrophenol (88891). The mononitrophenols were moderately toxic to animals, causing initial stimulation and subsequent depression of the respiratory and central nervous systems. Positive results were obtained in several mutagenicity assays for 3-nitrophenol and 4-nitrophenol. 2,4,-Dinitrophenol was far more acutely toxic than other important nitrophenol derivatives. It was able to uncouple oxidative phosphorylation by suppressing the coupling of electron flow to synthesis of adenosine-triphosphatase. It caused weakness, intense thirst and sweating, increased body temperature and respiration rate, neuritis, convulsions, and the rapid onset of rigor mortis after death. It has also caused cataracts in humans when used as a weight reducing aid. Inhalation of 2,4,6-trinitrophenol has caused considerable irritation to the eyes and to the mucous membrane of the respiratory tract. Dermal exposure has produced severe skin irritation and sensitization.
Keywords
  • Industrial medicine
  • Nitrophenols
  • Toxicity
  • Exposure
  • Chemical analysis
  • Utilization
  • Production
  • Occupational safety and health
  • Toxic substances
  • Biological effects
  • CAS 88-75-5
  • CAS 554-84-7
  • CAS 100-02-7
  • CAS 51-28-5
  • CAS 88-89-1
Source Agency
  • National Institute for Occupational Safety and Health
NTIS Subject Category
  • 57U - Public Health & Industrial Medicine
  • 57Y - Toxicology
  • 41I - Job Environment
  • 94D - Job Environment
  • 68G - Environmental Health & Safety
Corporate Authors Syracuse Research Corp., NY. Center for Chemical Hazard Assessment.; National Inst. for Occupational Safety and Health, Rockville, MD.
Supplemental Notes Sponsored by National Inst. for Occupational Safety and Health, Rockville, MD.
Document Type Technical Report
Title Note Draft rept. (Second).
NTIS Issue Number 198921
Contract Number
  • PHS-NIOSH-210-79-0030
Information Profiles on Potential Occupational Hazards: Nitrophenols.
Information Profiles on Potential Occupational Hazards: Nitrophenols.
PB89215842

  • Industrial medicine
  • Nitrophenols
  • Toxicity
  • Exposure
  • Chemical analysis
  • Utilization
  • Production
  • Occupational safety and health
  • Toxic substances
  • Biological effects
  • CAS 88-75-5
  • CAS 554-84-7
  • CAS 100-02-7
  • CAS 51-28-5
  • CAS 88-89-1
  • National Institute for Occupational Safety and Health
  • 57U - Public Health & Industrial Medicine
  • 57Y - Toxicology
  • 41I - Job Environment
  • 94D - Job Environment
  • 68G - Environmental Health & Safety
  • PHS-NIOSH-210-79-0030
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