| Abstract |
Information profiles were prepared for the following aminoazobenzenes: 4-aminoazobenzene (60093), 4-aminoazobenzene-3, 4'-disulfonic-acid (101508), 4-aminoazobenzene-3, 4'-disulfonic-acid-disodium-salt (2706287), 4-aminoazobenzene-hydrochloride (3457985), 4'-aminoazobenzene-4-sulfonic-acid (104234), 4'-aminoazobenzene-4-sulfonic-acid-sodium-salt (2491716), ortho-aminoazotoluene (97563), ortho-aminoazotoluene-hydrochloride (2298137), C.I.-Disperse-Orange-3 (730405), C.I.-Disperse-Red-1 (2872528), C.I.-Disperse-Red-5 (3769571), C.I.-Disperse-Red-17 (3179893), C.I.-Disperse-Yellow-3 (2832408), chrysodine (532821), 2,4-diaminoazobenzene (495545), and N,N,-diethylaminoazobenze (2481949). Information suggested that these compounds were only mildly toxic following acute exposure. Organ damage was noted in the liver, kidneys, and spleen following subchronic or chronic exposure. After metabolic activation in the Ames assay, positive findings were obtained for 4-aminoazobenzene, chrysodine and ortho-animoazotoluene. Aminoazobenzenes, 4-aminoazobenzenes, chrysodine and ortho-aminoazotoluene have tested positively in carcinogenicity studies using laboratory mice. Ortho-aminoazotoluene crossed the placenta and increased tumor incidence in the F1 generation. |
